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研究生: Hafiz Abbad Ur Rehman
Hafiz Abbad Ur Rehman
論文名稱: 甲狀腺疾病診斷的深度學習和機器學習方法研究
Study on Deep Learning and Machine Learning Methods for the diagnosis of Thyroid Disease
指導教授: 林其禹
Chyi-Yeu Lin
蘇順豐
Shun-Feng Su
口試委員: 林其禹
Chyi-Yeu Lin
蘇順豐
Shun-Feng Su
黃有評
Huang You ping
王偉彥
Wang Weiyan
王文俊
Wang Wenjun
周至宏
Zhou Zhihong
蔡清池
Cai Qingchi
學位類別: 博士
Doctor
系所名稱: 工程學院 - 機械工程系
Department of Mechanical Engineering
論文出版年: 2021
畢業學年度: 110
語文別: 英文
論文頁數: 84
中文關鍵詞: Deep LearningThyroidMedical ImagingHealthcareMachine LearningIridology
外文關鍵詞: Deep Learning, Thyroid, Medical Imaging, Healthcare, Machine Learning, Iridology
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  • This dissertation focuses on the use of deep learning and machine learning techniques to diagnose Thyroid Disease. Those techniques have recently made unprecedented progress and exhibit incredible abilities to discover intricate structures from high dimensional data. Deep learning approaches have achieved state-of-the-art performances by a significant margin for many computer vision tasks in various cases. The contributions of this dissertation are stated in three folds. First, a fast screening approach leveraging deep learning is proposed to solve the thyroid nodules problem. Second, the importance and effectiveness of medical data fusion are illustrated in developing machine learning classifiers. Third, the potential use of the deep learning model and iridology can address medical images for the thyroid problems. In particular, we investigate deep learning and machine learning ways of addressing classification, detection, segmentation of medical images for thyroid disease. For classification, a newly developed dataset has been used with fewer attributes for the early prediction of thyroid disease to allow doctors to get more precise and accurate results in less time. For detection and classification, the motivation is to provide a quick, supportive, non-invasive system for physicians to screen thyroid disorder through human iris images. For the segmentation, to distinguish between healthy tissues and the thyroid nodule region, an automated deep learning technique is used for detecting and segmenting thyroid nodules in ultrasound images. Experimental results demonstrate that the developed computational methods in this study are effective and efficient in learning from medical imaging data.


    This dissertation focuses on the use of deep learning and machine learning techniques to diagnose Thyroid Disease. Those techniques have recently made unprecedented progress and exhibit incredible abilities to discover intricate structures from high dimensional data. Deep learning approaches have achieved state-of-the-art performances by a significant margin for many computer vision tasks in various cases. The contributions of this dissertation are stated in three folds. First, a fast screening approach leveraging deep learning is proposed to solve the thyroid nodules problem. Second, the importance and effectiveness of medical data fusion are illustrated in developing machine learning classifiers. Third, the potential use of the deep learning model and iridology can address medical images for the thyroid problems. In particular, we investigate deep learning and machine learning ways of addressing classification, detection, segmentation of medical images for thyroid disease. For classification, a newly developed dataset has been used with fewer attributes for the early prediction of thyroid disease to allow doctors to get more precise and accurate results in less time. For detection and classification, the motivation is to provide a quick, supportive, non-invasive system for physicians to screen thyroid disorder through human iris images. For the segmentation, to distinguish between healthy tissues and the thyroid nodule region, an automated deep learning technique is used for detecting and segmenting thyroid nodules in ultrasound images. Experimental results demonstrate that the developed computational methods in this study are effective and efficient in learning from medical imaging data.

    Table of Contents Abstract i Acknowledgement ii List of Tables vi List of Figures vii Chapter 1. Introduction 1 1.1. Background 1 1.2. Motivation 3 1.3. Contribution 4 1.4. Thesis Outline 6 Chapter 2. Experimental Techniques 7 2.1. Machine Learning Techniques 7 2.1.1. Supervised Learning 7 2.1.1.1 KNN 7 2.1.1.2 Support Vector Machine (SVM) 9 2.1.1.3 Naive Bayes 10 2.1.1.4 Decision Tree 11 2.1.1.5 Logistic Regression 12 2.2. Deep Learning Techniques 13 2.2.1. Convolutional Neural Network (CNN) 13 2.2.1.1 Data Input Layer 13 2.2.1.2 Convolutional Layer 13 2.2.1.3 Pooling Layer 13 2.2.1.4 Full Connection Layer 14 2.3. Image Segmentation 14 2.3.1. Semantic Segmentation 14 2.4. U-Net Model 14 2.5. VGG-16 Model 15 Chapter 3. Deep Learning Based Fast Screening approach on Ultrasound Images for Thyroid Nodules Diagnosis 16 3.1. Introduction and Related Work 16 3.2. Method 18 3.2.1. Dataset Collection 18 3.2.2. Annotation 18 3.2.3. Methodology 19 3.2.4. Training Methodology 21 3.2.5. Proposed Convolutional Neural Network (CNN) Architecture 21 3.3. Results 23 3.3.1. Evaluation Metrics 24 3.3.2. Performance Evaluation Analysis 24 3.3.3. System Description and Time Analysis 25 3.3.4. Performance Comparison with Other State-Of-The-Art Methods 25 3.4. Summary 27 Chapter 4. Performance Analysis of Machine Learning Algorithms for Thyroid Disease 28 4.1. Introduction and Related Work 28 4.2. Methods 29 4.2.1. Dataset Collection 29 4.2.2. Methodology 31 4.2.3. Feature Selection 32 4.2.4. L1 Feature Selection 32 4.2.5. Chi-Square based feature selection 32 4.3. Results 34 4.3.1. Performance evaluation metrics 34 4.3.2. Experimental results Analysis 35 4.4. Related existing studies 40 4.5. Summary 40 Chapter 5. Intelligent Diagnosis of Thyroid Using Deep Learning Method and Iridology 42 5.1. Introduction and Related Work 42 5.2. Method 44 5.2.1. Dataset Collection 44 5.2.2. Training Methodology 45 5.2.3. Methodology 45 5.2.4. Thyroid Pathology 45 5.2.4.1. Conventional Method 46 5.2.4.2. Iridology 46 5.2.5. Proposed Convolutional Neural Network (CNN) Architecture 50 5.2.5.1. CNN Model-1 50 5.2.5.2. CNN Model-2 52 5.3. Results 54 5.3.1. Evaluation matrices 54 5.3.2. Quantitative Evaluation with Statistical Analysis 55 5.3.2.1. Experiment 1: CNN Model-1 55 5.3.2.2. Experiment 2: CNN Model-2 57 5.3.3. Discussion 59 5.4. Summary 60 Chapter 6. Conclusions and Future Work 61 6.1. Conclusions 61 6.2. Future Work 61 List of Publications 63 References 64

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