繁忙的社會裡，生活上的習慣以及不良的姿勢對脊椎健康有很大的影響，長期的動態負載會造成脊椎椎間盤病狀、背部疼痛，臨床上顯示腰、薦椎較為常見，因此可了解負載對脊椎的重要性。脊椎病情若在長期沒有得到治理情況下，椎間盤會有退化性的改變，使得負載超過椎間盤之纖維環強度，造成椎間盤凸出，脊髓神經遭受壓迫則會有疼痛或痲痺的情況。在輕微的病情下，可以藥物控制及復健作治療；嚴重者近來以微創方式替代傳統的手術作治療，而過程中對椎間盤有穿刺的動作，因此研究穿刺傷害對椎間盤在勁度上的影響。

由於人體試樣的不易獲得，並且豬隻試樣在幾何形狀較其他動物近似人類脊椎，因此取用豬隻試樣取代人體試樣作研究，以0.1、1、10 mm/min等三個不同的負載速率作測試，各別取用8個胸椎運動單元第二節至第九節(T2∼T9)作為實驗之試樣，共24個試樣。利用材料測試機(MTS, Instron 8872)對試樣施加軸向均佈壓縮負載，量測900 N內健康完整及穿刺的椎間盤之負載-位移關係進而求得其勁度來比較二者之間的不同。

結果顯示在軸向均佈負載於400-800 N下，軸向速率為0.1 mm/min時，健康完整的椎間盤勁度為1964.1N/mm，而受穿刺傷害的椎間盤勁度為2531.1N/mm；軸向速率為1 mm/min時，健康完整椎間盤之勁度為3023.9 N/mm，而穿刺受傷害的椎間盤之勁度為3678.0N/mm；軸向速率為10 mm/min時，健康完整的椎間盤之勁度為3632.8 N/mm，而穿刺受損害的椎間盤之勁度為 4371.1 N/mm。以變異數分析(ANOVA)探討穿刺傷害對於椎間盤平均勁度之影響得到顯著性結果；而負載速率對椎間盤勁度有顯著影響。

當軸向速率越快時，勁度增加的也越快，故椎間盤勁度與軸向負載速率成正比關係。經過實驗數據統計，發現在健康完整及以針穿刺受損害的椎間盤之勁度是有所不同的，在三組負載速率下，受穿刺傷害的椎間盤之平均勁度於400 N後皆比完整的椎間盤之平均勁度來的大，因此在脊椎術後仍應須注意椎間盤之情況，並且重視休息及復健與藥物控制來保護脊椎。

In the modern society, the habit and inappropriate posture in life influence on our health greatly, such as intervertebral disc changed pathologically and low back pain caused by long-term dynamic load. From the clinical results, the injuries are commonly happened in the lumbar spine and scrum which may cause the degeneration of the disc, and cause the disc herniated as the pressure higher than strength of annulus fibrosus. The patients may be cure by surgery, but the stabs injury left on the vertebrae and affected the stiffness of disc.

Because the structure and geometry of porcine specimens are similar to the specimens of human been and adopted in this thesis. 24 motion segment of porcine thoracic vertebras as the experiment specimens to be tested under different loading rate of 0.1, 1, 10 mm/min respectively which given by material test system(MTS, Instron 8872), and the load-displacement relation of intact and stab injury specimens within 900 N were measured and calculated the differences in stiffness of specimens.

From the results, as axial uniform load and loading rate was under 400〜800 N , 0.1 mm/min, 1 mm/mm and 10 mm/mm, respectively, the mean stiffness of intact specimens were 1964.1 N/mm, 3023.9 N/mm and 3632.8 N/mm, respectively, and the mean stiffness of injured specimens were 2531.1 N/mm, 3678.0 N/mm and 4371.1 N/mm, respectively. The loading rate has significant factor on the stiffness of disc of stab injured by using that analyzed by using analysis of variance(ANOVA) analysis.

The higher loading rate the higher stiffness of disc as well, proportionally. From the statistical results, as the loading was higher than 400 N, the mean stiffness of stab injured disc was higher than the mean stiffness of intact disc.

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