幾丁聚醣為一種生物性高分子，具有良好的生物相容性、無毒性、生物分解性、抗菌性，且在地球的蘊藏含量僅次於纖維素，而且可從廢棄的蝦蟹殼中大量取得等優點，所以被廣泛應用於醫用材料。
二苯基甲烷二異氫酸鹽（4,4- Diphenylmethane Diisocyanate，簡稱MDI）是最重要的聚胺酯原料之一，其機械性優異、反應快及易加工性特性。主要應用於製造聚氨酯彈性體、人造皮革、合成皮、織物塗層整飾劑，人體器官代用品等。
本文主旨在探討以天然高分子幾丁聚醣(Chitosan)與二苯基甲烷二異氰酸酯(MDI)依不同比例進行反應，於室溫下控制幾丁聚醣水溶液之不同濃度,直接進行反應,由於幾丁聚醣的化學結構,具有很多-OH官能基，故利用氫氧基團反應性，進行原位聚合發泡之反應，可簡易的獲得聚氨酯(PU)架橋發泡反應體。利用SEM、發泡倍率、密度、吸水性、水蒸氣透過率、應力應變等實驗，分別探討異氫酸鹽改質幾丁聚醣之反應性及物性之影響效應，得知MDI含量越多，造成薄膜孔洞越大，發泡倍率、吸水率提升，相對的密度、水蒸氣透過率及應力應變降低。同時藉由DMA及TGA了解，MDI對熱性質影響效應，MDI能有效的提升薄膜的耐熱性以及改善Chitosan的脆性剛性。並使用革蘭氏陽性菌(黃金葡萄球菌)和革蘭氏陰性菌(大腸桿菌)來進行外在環境之生物抗菌能力，以探討Chitosan/MDI配比對於抗菌性之影響效應，並得知Chitosan含量越多其抗菌率越高，抗菌效果也越好。

Chitosan is a biological polymer. It has good biological compatibility, avirulence, degradable and antibiotic. Besides, the storage on the earth is after cellulose. The advantage is that it can be obtained from the waste shell of shrimp and crab. Therefore, it is widely used on medical material.
MDI is one of the most important material for PU. The characteristics involve that the machinery is excellent, reaction is fast and processing is easy. It is mainly used to produce PU elastomer, artificial leather,synthesized skin, fabric coating dress down agent and human organ substitute.
The objective of this article is to discuss the reaction of nature Chritosan macromolecule and MDI with different proportion. The different concentration of Chitosan solution reacts directly under room temperature. The chemical structure of Chitosan contains many -OH base. Therefore, the reactivity of oxyhydrogen base is utilized to process in situ polymerization expansion reaction. The bridging expansion reaction agent of PU can easily be obtained. The experiments on SEM, expansion ratio, density, water absorption, and W.V.T and stress strain are used in order to study the effect of reactivity and physical property of Diisocyanate changed Chitosan. It is found that when the content of MDI is more, the size of hole on membrane is larger. The expansion ratio and hydroscopicity raise, and the relative density, vapor penetration rate and stress strain decrease. Besides, from the DMA and TGA, the effect of thermal property is found. MDI can effectively raise the thermostability of the membrane, and improve the brittleness and rigidity of Chitosan. The Staphylococcus andEscherichia are used to test the biological antiseptic ability in external environment in order to study the effect of Chitosan/MDI proportion on bacteria resistance. It is found that when the content of Chitpsan is more, the bacteria resistance is higher and the antiseptic result is better.

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