疏水性幾丁聚醣(Hydrophobically modified chitosan)是由十二烷基醛和幾丁聚醣(chitosan)的反應合成，並利用長疏水鏈達到止血的功能。在此篇研究中，將分別由血液及大腸桿菌液作疏水性幾丁聚醣凝血能力的說明。
此外我們也特別探討疏水性幾丁聚醣之泡沫態穩定性質。疏水性幾丁聚醣接枝於磁性微珠表面，並經由添加磁場來有效地移除凝血細胞。其中幾丁聚醣、疏水性幾丁聚醣及疏水性幾丁聚醣接枝磁性微珠之特性將利用傅立葉紅外光譜儀、元素分析、電子顯微鏡和熱重分析儀進行分析。疏水性幾丁聚醣之去乙醯化和取代程度分別為81%和11%。此篇研究中我們利用葛蘭氏陰性菌(例如:大腸桿菌)細胞膜與磁性微珠疏水端間的作用來描述其捕捉能力。

Hydrophobically modified chitosan (HMCS) was synthesized by reacting dodecyl aldehyde with chitosan (CS). HMCS has been reported to have a good hemostatic property. It can coagulate blood cells via its hydrophobic tails. In this work, HMCS was synthesized and its capability on coagulating blood cells and E. coli was demonstrated, respectively. In addition, the strong foam stabilization effect of HMCS was also demonstrated. In order to generate coagulated cells which can be moved by applying magnetic field, HMCS was grafted to the surface of magnetic micro-particles (MMPs). The characterization of CS, HMCS, HMCS grafted MMPs were carried by Fourier transform infrared spectroscopy (FTIR), elemental analysis (EA), SEM, TGA. The degree of deacetylation (DDA) and degree of substitution (DS) of HMCS are 81% and 11%, respectively. The HMCS modified MMPs has demonstrated its capability for capturing Gram-negative bacteria such as E. coli due to the hydrophobic interaction between the hydrophobic tail of HMCS and outer membrane of E. coli.

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