目前在治療結腸阻塞(colonic obstruction)方面，常以自擴式金屬支
架（self-expandable stents, SEMS）作為緊急手術的替代方案，但腸道
支架置入後可能產生支架移位(migration)、穿孔(perforation)等併發症，
仍是急待解決的問題。可能之解決方法為以可生物降解支架取代
SEMS 來治療結腸阻塞，但大直徑的可降解支架卻面臨支架缺乏足夠
機械性能之瓶頸，目前仍無適用於治療結腸阻塞的可降解支架。
有鑑於此，本實驗室提出結合薄膜型支架模具及充填式技術之充
填式可降解腸道支架的製程概念，藉此降低併發症的發生率，並提供
足夠的徑向力以維持腸道的擴張。本研究的主要目的是探討此製程概
念的可行性，實驗方法是將經由快速降解支架製作出來的薄膜型支架
模具，透過收縮測試、注水測試，以及充填光固化測試，以確認此製
程是否可行，並模擬分析此支架的徑向力。實驗結果顯示，藉由此方
法可成功地製作出可提供足夠徑向力的充填式薄膜支架，也證實了此
製程概念的可行性，對於未來克服可生物降解支架的瓶頸，具有一定
的突破與貢獻。

At present, self-expandable metal stent (SEMS) is as an alternative to
emergency surgery in the management of colonic obstruction, but there
are still several significant complications after colorectal stent placement.
Although the biodegradable stent is an attractive alternative to SEMS in
the treatment of intestinal strictures now, the large-diameter
biodegradable stents face a bottleneck, the lack of sufficient mechanical
properties. There are still no available biodegradable stent for the
treatment of colonic obstruction currently.
To solve this problem, our research group proposes a method for
fabricating biodegradable colonic stents that combines the thin film-type
stent mold and filling technology to reduce the incidence of
complications and provide sufficient radial force to maintain colonic
dilatation.The main purpose of this research is to investigate the
feasibility of this process concept. To confirm whether the method is
feasible, the thin film-type stent mold that is made out by a rapid
degradation stent is tested by crimping test, filling test, and light curing
test. In addition, ANSYS software is used to simulate the radial force of
this stent. According to the result of this study, the filling film-type stent
that may provide sufficient radial force is fabricated successfully by this
method. This study not only proofs that the concept of this fabricating
method is feasible, but also contributes to overcoming the bottlenecks of
biodegradable stents currently.

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