此次論文主要探討的內容以胞外泌體為主，並透過有機電化學電晶體(OECT)、電化學電聚合、及黃光為影等技術，來完成生物晶片的整合，並達到生物電子感測的目的，以導電高分子系作為材料，並利用電化學電聚合的方式做出三維結構之生物電子薄膜介面，使用其薄膜捕獲胞外泌體(Exosome)，因為上述電化學電聚合法可成功製備在OECT的主動層通道上，我們後續利用OECT作為感測元件對胞外泌體進行生物感測效能之探討。本實驗將分成以下步驟進行;(i)首先優化指叉式電極結構利用黃光微影的方式做出以玻璃為基板且金作為電極之指叉式電極晶片，並設計不一樣的通道線寬以優化OECT之跨導率(Transconductance)和開關效應(ON/OFF ratio);(ii)將含有羧酸官能基之乙基二氧噻吩單體(EDOT-Ac)使用電化學電聚合的方式形成高分子薄膜於指叉式電極上，以調控溫度來形成薄膜表面奈米管柱結構;(iii)表面修飾晶片使用聚（L-賴氨酸）-接枝-聚（乙二醇）-生物素(PLL-g-PEG-biotin)，並結合鏈黴親和素(Streptavidin, SA)及上皮細胞黏附分子(Anti-EpCAM)對特定胞外泌體進行捕獲;(iv)以電化學電聚合造成的形貌差異改善胞外泌體捕獲效率，再以奈米粒子追蹤分析儀(NTA)計算其捕獲效率;(v)為了佐證捕獲帶來的影響，再利用跨導率(Transconductance)、循環伏安法(CV)、電化學阻抗譜(EIS)等方式來了解胞外泌體在生物電子中的特性，因為在胞外泌體對於生物電子中的研究尚不廣泛，作為新興生物電子的感測目標物，期許在未來能夠將此生物電子技術應用到臨床診斷及治療上。

The main content of this paper is exosomes, and the integration of biochips is completed through organic electrochemical transistors (OECT), electrochemical electropolymerization, and yellow light filming and other technologies to achieve bioelectronics. The purpose of sensing is to use the conductive polymer system as the material, and use the electrochemical electropolymerization method to make a three-dimensional structure of the bioelectronic film interface, and use the film to capture the exosomes (Exosome), because the above electrochemical electropolymerization method It can be successfully prepared on the active layer channel of OECT. We will use OECT as a sensing element to explore the biosensing efficiency of exosomes. This experiment will be divided into the following steps: (i) First, optimize the structure of the interdigitated electrode to make an interdigitated electrode wafer with glass as the substrate and gold as the electrode by yellow light lithography, and design different channel line widths to optimize Transconductance and ON/OFF ratio of OECT; (ii) The ethyldioxythiophene monomer (EDOT-Ac) containing a carboxylic acid functional group is formed into a polymer by electrochemical electropolymerization The thin film was deposited on the interdigitated electrode, and the temperature was controlled to form the nanotube column structure on the surface of the thin film; (iii) the surface modification wafer used poly(L-lysine)-graft-poly(ethylene glycol)-biotin ( PLL-g-PEG-biotin), combined with streptavidin (SA) and epithelial cell adhesion molecule (Anti-EpCAM) to capture specific exosomes; The difference in morphology improves the capture efficiency of exosomes, and the capture efficiency is calculated by nanoparticle tracking analyzer (NTA). (CV), electrochemical impedance spectroscopy (EIS) and other methods to understand the characteristics of exosomes in bioelectronics, because the research on exosomes in bioelectronics is not yet extensive, as a sensing target for emerging bioelectronics It is expected that this bioelectronic technology can be applied to clinical diagnosis and treatment in the future.

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