本次實驗是利用矽膠的阻水性及透氣性來達到抑制、減少增生性疤痕的產生。本篇將探討體外模擬及動物實驗模式來驗證矽凝膠及矽膠貼片之功效。首先，體外模擬採用了豬皮作為皮膚的替代物，比較有塗抹矽凝膠與未塗抹矽凝膠的豬皮在水分散失速度上的差異。經實驗後，未塗抹矽凝膠的豬皮在12小時的失重率約為22%，而有塗抹矽凝膠的豬皮在12小時失重率為11%。上述可說明矽凝膠在豬皮的失重率上有顯著差異。此外，在矽膠貼片的部分主要使用MED6345這個產品。當純的MED6345遇到較濕潤的環境時，黏著力會下降。因此本次實驗中添加了Tris-co-Vp的共聚物來提升MED6345在濕潤態下的黏著力。在添加共聚物的矽膠貼片與未添加的矽膠貼片，利用豬皮模擬皮膚做拉伸試驗來檢測乾燥狀態下與濕潤狀態下矽膠貼片的黏著力。測試結果得出在乾燥狀態下矽膠貼片有添加共聚物或未添加共聚物的都有3.5-4N的黏著力表現。而在濕潤狀態下添加1至2%的共聚物時黏著力可以達到2.8-3N之間的黏著力;未添加共聚物的只剩0.8N的黏著力。因此添加共聚物會有效提升矽膠貼片在濕潤態下的黏著力。
最後利用動物實驗來驗證矽凝膠與矽膠貼片對於抑制、減少增生性疤痕的功效。採用BALB/c這一品系的老鼠作為動物實驗模擬的品系，在其背上製造出兩個相似的傷口。一個做為實驗組給予材料而另一個作為對照組，利用自體比較的方式以減少個體間差異而影響傷口癒合速度。透過疤痕指數計算對照組在1.11，實驗組在1.04-1.06之間(針對增生性疤痕當疤痕指數為1時，代表與原本皮膚無差異)不管是矽凝膠還是矽膠貼片皆有達到抑制、減少疤痕的效果。

In this experiment, the water resistance and air permeability of silicone gel and silicone sheet to inhibit and reduce the hyperplastic scars. In vitro simulation and animal experiment models to verify the efficacy of silicone gel and silicone sheet will be discussed in this thesis. First, pig skin was used to simulation the human skin to compare percentage of weight loss between silicone gel application and without silicone gel application. For the result, the weight loss percentage of pig skin without silicone gel was about 22% at 12 hours, while the weight loss rate of pig skin with silicone gel was about 11% at 12 hours. These results indicate that the silicone gel has a significant difference in the weight loss percentage of pig skin. Furthermore, MED6345 is mainly used in the part of the silicone sheet. When the pure MED6345 in moist environment, the adhesion will decrease. Therefore, Tris-co-Vp copolymer was added to improve the adhesion of MED6345 in moist environment. In the silicone sheet with the copolymer and the silicone sheet without addition, a tensile test is performed on the simulated skin of pig skin to detect the adhesive force of the silicone sheet in the dry and moist conditions. The test results showed that the silicone sheet with or without copolymer had a performance of 3.5-4N in the dry state. As 1 to 2% of the copolymer is added in the moist conditions, the adhesion still have about 3N; the unadded only has about 0.8N. Therefore, the addition of copolymer can effectively improve the adhesion of the silicone sheet in the wet state.
Finally, animal experiments were used to analyze the effectiveness of silicone gel and silicone sheet for reducing hyperplastic scars. Two similar wounds were created on the backs of mice using the BALB/ C breed. Each mice have two wounds on the back, one was treated as the experimental group and the other nontreated as the control group. Self-comparison was used to reduce the difference between individuals and affect wound healing. According to the scar index calculation, the control group was around 1.11 and the experimental group was around 1.05 (for hyperplastic scars, when the scar index was 1, it meant no difference from the original skin) both silicone gel and silicone sheet could inhibit and reduce scars.

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