植入性醫療器械，透過外科手術將醫療器械植入人體內，如整形外科、心血管支架、藥物遞送系統等。因需長時間置留在人體內，作為此器械之材料即面臨生物相容性是否良好、是否具有抗菌性和是否造成血管栓塞等問題。由於金屬玻璃其無序的原子排列結構，因此擁有許多獨特的性質，如高強度、抗腐蝕性、較佳的生物相容性及抗細菌沾黏等，於醫療應用上應有很大的潛力。
本研究使用磁控濺鍍系統鍍製鋯基金屬玻璃薄膜(Zr53Cu33Al9Ta5)及純鈦薄膜於醫療級玻璃片上，探討表面粗糙度、血液接觸角與血小板附著之相互關係，並從血小板團聚情形推論血栓形成的機會。粗糙度量測結果，鍍有金屬玻璃之留置針及醫療級玻璃表面，粗糙度分別可降低 42%及27%。接觸角實驗結果，去離子水 (DI water) 於鍍有金屬玻璃薄膜表面接觸角度更高於90°(97.7°)，證實鍍有金屬玻璃表面呈現疏水的特性。進一步以豬、兔子和人的全血液(whole blood)及血清(serum)進行接觸角量測，鍍有金屬玻璃薄膜的醫療級玻璃片，於不同生物體之全血液及血清的接觸角度皆比鍍有鈦金屬薄膜及未鍍的玻璃片接觸角度大，表示血細胞較不易黏附於其上。經蘭嶼黑豬及人類血小板附著實驗，以掃描式電子顯微鏡觀察，表面鍍有金屬玻璃薄膜的醫療級玻璃片，血小板附著所佔據SEM影像面積的百分比分別為0.34%及0.62%，與未鍍的醫療級玻璃片相比，血小板附著所占據SEM影像面積百分比明顯減少80%及89%。蘭嶼黑豬及人類血小板大小相對血小板數量作圖，於鍍有金屬玻璃之醫療級玻璃片，血小板最大團聚面積僅22 μm2及7 μm2，未鍍的醫療級玻璃片血小板團聚面積則大至190 μm2及680 μm2。依據上述實驗結果，表面鍍有金屬玻璃薄膜的醫療器械，血小板附著數量及團聚情形明顯減少，推論血栓形成機率及引發感染發炎情形可能降低，可延長醫療器械的壽命，提升器械的使用價值。

Intravenous catheters are widely used in hospitals as the safe and essential pipelines to provide intravenous treatments, such as injections of medicine and nutritional supplements. Generally, the catheter is remained in a vein for some periods of time. It is easy to increase the opportunity of the phlebitis and sepsis due to the bacterial infection. Thin film metallic glass (TFMG) exhibits unique properties such as high strength, smooth surface as well as good wear- and corrosion-resistances due to its random-packing atomic structure. The biocompatibility and antibacterial property of TFMG can also be achieved, suggesting great potential for biomedical applications.
In this study, Zr-based TFMG was deposited on catheter and medical-grade glasses by magnetron sputtering in order to decrease the chance for forming venous thrombosis. Surface roughness values of Ti-coated and bare glasses are similar, whereas the TFMG-coated one has relatively smooth surface. The Rq (root mean square) value of the bare glass is ~0.25 nm, which slightly decreases to 0.23 nm (a ~8% reduction) after coating with Ti and noticeably decreases to 0.19 nm (a ~27% reduction) after coating with TFMG. Based on the contact angle measurement results of various fluids on glass, the TFMG-coated glass exhibits more hydrophobic than that of bare one. The water contact angle of the bare sample surface is 60.1°, and this angle increases by ~63% after coating with TFMG (97.7°). There are less platelets aggregating on TFMG than on the bare glass in platelet adhesion test. According to experimental results, it is suggested that TFMG-coated catheters can be inserted into vessels for long periods of time with reduced numbers of the aggregation of blood platelets.

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