隨著科技的發展，虛擬實境（Virtual Reality）頭戴式設備（Head Mounted Device）現已廣泛應用於各個領域，除了給人身臨其境的體驗，也帶來眩暈及不適感，稱之為動暈症（Cybersickness）。因此，近年來，關於虛擬實境中動暈症的討論越來越多，然而少有關於瞳孔變化的討論。本研究探討虛擬實境中瞳孔變化和動暈症的關聯性，評價方法為使用問卷獲得主觀評價以及客觀生理測量的資料分析。 Robert S. Kennedy等人提出的模擬器動暈症疾病問卷包含16種症狀，根據類別不同計算出四種得分，包含噁心、動眼神經不適和迷失方向以及總體得分，可以透過此問卷了解受測者的主觀感受，客觀生理資訊包含瞳孔直徑及心律變異度變化，藉由人因實驗研究不同動暈症程度是否對瞳孔資訊及心律變化有差異，並使用量化方法進行分析。
在這項研究中，使用HP Reverb G2 Omnicept Edition頭戴式設備記錄30名受測者在虛擬實境實驗中的心率變異度和瞳孔直徑變化，實驗結果表明，在受測者主觀自評動暈症症狀發生，以及心率變異度數據中時域分析指標SDNN和RMSSD皆有顯著下降時，瞳孔大小變化量與動暈症相關，並具有統計上的顯著性，本研究也初步發現主觀評價問卷中的動眼神經不適分數變化量與SDNN值呈正相關；噁心評分與瞳孔大小的變異性呈負相關。討論性別間的差異，分析結果顯示女性受動暈症影響程度較男性嚴重，皮爾森相關係數分析還顯示，男性受試者的SDNN值與噁心、動眼神經不適和總分變化之間存在顯著高度正相關，女性受測者中，SDNN變化量和RMSSD變化量皆與主觀評價中噁心得分變化量之間存在顯著正相關，但難以排除個體差異，故結果有較大的標準差，進一步關於瞳孔及動暈症相關性的研究需要更多的參與者，本研究已初步發現兩者間相關性，但更詳細的關係需要進行更大型的實驗。

With the development of science and technology, Virtual Reality (VR) head- mounted devices (HMD) are now widely used in various fields. However, besides giving people an immersive experience, they also bring dizziness and discomfort to others. Therefore, increased discussion has raised on topics in cybersickness in virtual reality over the recent years. At present, it is pointed out that the best way to evaluate motion sickness is to use both questionnaires and psycho-physiological measurements. The Simulator Sickness Questionnaire contains 16 types of sickness divided into three categories: nausea, oculomotor, and disorientation. We can subjectively judge the degree of illness through participants' feelings with the questionnaire.
We propose of to find the correlation between cybersickness and psychophysiological data through conducting VR experiment. In this study, the HP Reverb G2 Omnicept Edition head-mounted device were utilized to record Heart Rate Variability (HRV) and measurements of pupilometer during VR experiment with 30 participants.
Our experimental results indicated that the metrics of SDNN and RMSSD in HRV data and pupil size variability are also quantitatively associated with SSQ scores. Moreover, we showed that the cyber-sickness oculomotor scores was positively correlated with SDNN values and nausea scores was negatively correlated with pupil size variability.

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