奈米複合材料因其具有極小的粒徑以及極大的表面積而提供了獨特的物理、化學及生物性質，所以廣泛的應用於生物醫學領域。在本研究中，氧化石墨烯將作為主要的基材，因氧化石墨烯在水中良好的分散性能避免其聚集成大顆粒，而其表面也具有豐富的氧化官能基團能與各種材料做結合與改質，像是金屬、高分子、等等。因此氧化石墨烯是一個非常適合用來當作奈米複合材料的基材。在本研究中，我們成功的製備了氟化樹狀高分子與氧化石墨烯之複合材料，其中，所使用之樹狀高分子分為胺基(-NH2)以及羥基(-OH)兩種。結果顯示NGO/Den(OH)-F複合物在水溶液狀態下具有良好的分散性及穩定性，反之，NGO/Den(NH2)-F複合物於水溶液狀態下則會產生聚集效應進而沉澱。另外，我們也使用含氟聚乙二醇(F-PEG)作為穩定劑，希望能使NGO/Den(OH)-F複合物形成更穩定的狀態，由Zeta電位得知，加入F-PEG後可得到較大的Zeta電位及穩定區間(|Zeta電位| > 30)，由此可知，NGO/Den(OH)-F複合物與含氟聚乙二醇經由氟與氟之間的疏水效應可以形成一高穩定的結構及狀態。綜合以上結果，NGO/Den(OH)-F複合物及含氟聚乙二醇系統將可作為一奈米載體進而用於藥物輸送系統或生物醫學應用。

Nano-composites offer interesting physicochemical and biological properties for biomedical applications because of their small size and large surface area. Graphene oxide (GO) is used as a main targeting material due to its rich oxygen-based functional groups and it can be easily functionalized with other unique materials, such as metals, polymers, etc. In this work, the NGO/Den-F composites were successfully synthesized with fluorine-containing dendrimer, which was prepared by different types of PAMAM dendrimer (-NH2 and -OH terminal). The dispersity and stability of NGO/Den(OH)-F composite in aqueous media is better than NGO/Den(NH2)-F composite because of the agglomeration of NGO/Den(NH2)-F composite. Furthermore, we also used fluorinated polyethylene glycol (F8-PEG2000) as a stabilizer in order to enhance the stability of the NGO/Den(OH)-F composite. From the results of zeta potential, we can obtain the higher value from the mixture of NGO/Den(OH)-F + F8-PEG2000, which means the F8-PEG2000 can increase the stability by hydrophobic interactions with NGO/Den(OH)-F composite. This indicates the possible application of the NGO/Den(OH)-F with F-PEG to be a novel nanocarrier for drug delivery system or biomedical applications.

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