現今普遍治療雄性禿（androgenetic alopecia）的方法有口服柔沛（finasteride）、外用生髮水（minoxidil）與植髮（hair transplantation），但這些方法的成效都各有其所無法突破的地方。近年經學者研究發現，於毛囊中萃取出之毛囊真皮乳頭細胞（dermal papilla cells）在體外大量增生後，再將其植入禿髮處，即可誘導毛囊新生。但現階段的植入方式為採用手術或注射器等方式置入細胞團，須耗費大量時間在細胞團製備及裝填的步驟上。為了縮短前置作業時間、加快植入效率及固定植入深度，具有細胞儲存能力之連續式細胞團植入器確有其開發的必要性。
本研究以先前研究之第一代連續式細胞植入器為基礎，藉由QFD、DFA與FMEA工具系統化地改良設計出第二代連續式細胞植入器，其同樣以將半固體狀的真皮乳頭細胞團放入「彈匣」中或直接於「彈匣」中進行培養，再利用器械的自動進給機制推送植入體透過針具進行植入的概念為設計初衷。第二代連續式細胞植入器之各零組件於3D繪圖軟體中繪製完成後，即以SDM製程與快速原型技術製作出原型零件，再將零件與針具結合組裝，隨後進行多項實驗比較其與先前研究的差異；並利用染色洋菜膠作為模擬植入體植入豬皮，切片後以放大鏡觀察其植入效果與植入深度並進行評估。測試結果發現第二代連續式細胞植入器具有相對舒適的操作方式，且其植入效果和速度都大幅的領先第一代連續式細胞植入器。

The general treatments of androgenetic alopecia include finasteride, minoxidil, and hair transplantation. Each of them has certain issues to break through. The recent study found that implanting the dermal papilla cells, which was extracted from the hair follicles and proliferated in vitro, in the bald areas can induce new hair follicles. However, the existing approaches to implant the cell aggregates are by surgery or syringe, requiring a lot of time on preparation and loading the cells. In order to shorten the preparation time, speed up the efficiency and control the implanted depth, development of a continous implanter which has cell storage capability is needed.
The concept of the continuous implanter is to place semi-solid dermal papilla cells or cultivate them directly in a cartridge, and an auto-feed mechanism is utilized to push the cells into the derma through a needle. In this research, QFD, DFA, and FMEA tools were adopted to systematically analyze the first generation continuous cell implanter developed in the previous study. Based on the analysis results, the second generation implanter was designed to improve its performance and reduce its assembly time and failure risk. All the components were designed in a 3D CAD software and fabricated their prototypes by SDM process or commercial rapid prototyping technique. After assembly of the components and the needles, several tests were conducted to compare with the first generation of continuous cell implanter. Moreover, dyed agar was used to simulate the cell aggregates implanting into porcine derma. The implanted biopsy samples were observed by a microscope. The results revealed that the second generation continuous cell implanter can operate easier and more comfortable. The effectiveness and speed of implanting are improved significantly.

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