近年來，二型糖尿病患者會產生胰島素阻抗導致血糖過高以及體重過重的問題，可透過腸套管裝置來控制腸道賀爾蒙分泌進而控制胰島素的分泌，達到控制血糖的效果。然而，應用於腸套管的薄膜必須承受腸胃蠕動所施予的應力而不受破壞，並且具有降解性而不會由於植入後移除過程造成腸壁組織產生傷害，因此本研究將惰性材料(Poly(vinylidene fluoride), PVDF)與降解材(Poly(butylene succinate), PBS)進行混摻，同時添加改質後的蒙脫土製備成具有降解性以及高機械強度的奈米複合材料，並將奈米複合材料製備成膜。當奈米複合材料的比例為PVDF90/PBS10/OMMT3wt%擁有最高的拉伸強度為62.61 MPa，達到植入生物的軟組織中所需的拉伸強度為46.5 MPa，挑選此比例的奈米複合材料與PBS薄膜植入大鼠的胃腸道（胃和十二指腸）中進行體內降解試驗。研究並比較奈米複合材料與PBS薄膜的降解情況。薄膜植入後一個月，分別取出並通過量測薄膜的重量損失、拉伸試驗和表面形態變化來確定降解程度。結果顯示，PBS薄膜在十二指腸區與胃區的降解程度皆高於奈米複合材料。在胃腸道中，來自胃酸與腸液的侵蝕提高PBS薄膜的降解程度，而奈米複合材表現出更佳的抗腐蝕性。奈米複合材在胃中的重量損失率為1.88%並且在十二指腸中的重量損失率僅為0.88%，結果顯示奈米複合材料在的降解速率比PBS薄膜慢。奈米複合材進行一個月的體內降解試驗其拉伸強度為60.85 MPa，依然維持高的拉伸強度。通過組織學檢查體內組織(胃和十二指腸)顯示輕度炎症和正常術後會出現的副作用。通過體內降解試驗判斷本研究的奈米複合材具有應用於腸套管之可行性。

Recently, type 2 diabetic patients with insulin resistance problem have caused hyperglycemia and overweight. This duodenal barrier treatment avoids the directly contact of food with duodenal wall and then the plasma glucose will be controlled through manipulate intestinal hormonal and insulin secretion. However, the film of duodenal barrier must withstand the stress exerted by enterogastric peristalsis and the gastrointestinal motility without being damaged and has degradability without causing damage to the intestinal wall due to the removal process after implantation. Therefore, in this study, poly(vinylidene fluoride) (PVDF) was first blended with biodegradable poly(butylene succinate) (PBS), and then added montmorillonite at the same time to prepared the polymer nanocomposite with degradability and high mechanical properties. The nanocomposite had the highest tensile strength of 62.61 MPa in the proportion of PVDF90/PBS10/OMMT3 wt%, which had reached the standard of tensile strength, 46.5 MPa, applying to soft tissue. This study explored the degradation of nanocomposite and PBS films through measuring the weight loss, tensile test and observing the change of microscopic surface after implanted in vivo for one month. The result indicated that the extent of degradation of PBS films are faster than nanocomposite in duodenum and stomach. In gastro intestinal tract, the attack of gastric acid and juice increased the extent of degradation of PBS films; however, nanocomposite showed better corrosion resistance. The rate of weight loss of nanocomposite in stomach was 1.88% and that of in duodenum was 0.88 %, which was less than the rate of weight loss of PBS films. The nanocomposite remained high tensile strength of 60.85 MPa after implanted one-month in vivo degradation test. Histological examination of the in vivo tissue revealed mild inflammation and negligible adverse effects. Through in vivo degradation test, the nanocomposites of this study have the feasibility of applying as biodegradable duodenal barrier.

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