在本研究中，利用綠色化學方法合成confeito狀金奈米粒子。此粒子將藉由紫外線/可見光分光光譜儀及穿透式電子顯微鏡測其光學性質和其形態。其獲得confeito狀金奈米粒子的平均粒徑約80奈米且其電漿子吸收帶(plasmon absorption band)為645奈米，且帶負電荷的檸檬酸鹽(citrate)覆蓋在confeito狀金奈米粒子表面並均勻分散於水中。此膠體粒子將濃縮至1、5和10mM，然後散佈到兩種不同表面修飾的氧化銦錫(ITO)基板上：一種是利用3-氨丙基三甲氧基硅烷(APTES)之自組裝薄膜於ITO上；另一種則是利用聚苯乙烯(PS)球之自組裝薄膜於ITO上再利用聚醯胺-胺樹枝狀聚合物修飾聚苯乙烯球表面。confeito狀金奈米粒子將吸附於這兩種基板上藉由浸塗法(dip-coating process) 隨後利用掃描電子顯微鏡來證實confeito狀金奈米粒子是否成功吸附於基板上。
表面增強拉曼散射(surface-enhanced Raman scattering)將測試羅丹明6G (Rhodamine 6G)染料於nanoassemblies。不同濃度的羅丹明6G溶液分別散佈於nanoassemblies，於514奈米激發光下進行羅丹明6G的拉曼散射測定。對於兩種基板，均可獲得強烈的拉曼散射訊號且證實confeito狀金奈米粒子具有SERS活性。PS/ITO基板的增強因子(enhancement factor)高達50,000且高於APTES-SAM/ITO基板5-10倍：由於PS/ITO基板保有較多的confeito狀金奈米粒子。由這些結果顯示其具有很大潛力於分子電子裝置以及超敏感分析的研究。

In this study, confeito-like gold nanoparticles (AuNPs) were synthesized with a green chemical method. The confeito-like AuNPs were characterized with UV-vis spectroscopy and transmission electron microscopy. The obtained AuNPs, which were 80 nm in average diameter and had plasmon absorption band at 645 nm, were protected by citrate with negative charge to be dispersed in water. These colloidal particles were concentrated to 1, 5, 10 mM, and then spread on two kinds of indium tin oxide (ITO) substrates; one was modified with a self-assembled monolayer of 3-aminopropyltriethoxysilane (APTES-SAM/ITO) and another was coated by a monolayer of polystyrene spheres following a coat of poly(amido amine) dendrimer (PS/ITO). The confeito-like AuNPs were adsorbed on the APTES-SAM/ITO and PS/ITO substrates by dip-coating process, and the presence of confeito-like AuNPs on these substrates was confirmed by scanning electron microscopy (SEM).
Using these nanoassemblies, the surface-enhanced Raman scattering (SERS) was examined with a dye, Rhodamine 6G (R6G), as a probe molecule. Solutions of R6G with different concentrations were respectively spread on the nanoassemblies, and the Raman scattering of R6G were measured under laser excitation at 514 nm. For the both substrates, the Raman scattering was strongly intensified, and the SERS activity of the confeito-like AuNPs were confirmed. The enhancement factor (EF) of the PS/ITO substrate was maximum 50,000 and it notably stronger by a factor of 5-10 than that of the APTES-SAM/ITO substrate: The PS/ITO substrate could maintain more AuNPs on its surface than the APTES-SAM/ITO substrate. These results indicate a great potential in the researches of molecular electronic devices and ultrasensitive analyses.

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