近年來，因為飲食與生活習慣的改變，冠狀動脈疾病（coronary artery disease, CAD）逐漸成為了人類社會中常見的疾病之一，裸金屬支架（bare metal stents, BMS）與藥物塗覆支架（drug eluting stents, DES）的植入是治療冠狀動脈疾病的主要方法，但裸金屬支架在植入早期有支架內再狹窄（in-stent restenosis, ISR）的發生，藥物塗覆支架也在植入後期發現晚期支架血栓（late stent thrombosis, LST）的形成，而支架植入後的再內皮化（re-endothelialization）是解決這些問題的關鍵，近年來研究指出，銅離子（Cu2+）可以促進血管內皮細胞的生長，因此，本研究透過磁控濺鍍法在316L不鏽鋼上分別鍍上Cu47Zr42Al7Ti4和Zr60Cu25Al10Ni5金屬玻璃薄膜（thin film metallic glass）進行特性分析，並評估其對人類臍帶靜脈內皮細胞（human umbilical vein endothelial cell）的影響。在316L不鏽鋼上鍍上Cu47Zr42Al7Ti4和Zr60Cu25Al10Ni5金屬玻璃薄膜，可使表面粗糙度與水接觸角降低，並有微量銅離子的釋放，提供人類臍帶靜脈內皮細胞較好的貼附條件及促進細胞增殖，而Cu47Zr42Al7Ti4金屬玻璃薄膜鍍層更提高了人類臍帶靜脈內皮細胞對於氧化壓力環境的耐受性，本研究證明Cu47Zr42Al7Ti4金屬玻璃薄膜做為冠狀動脈支架鍍層應具有高度潛力。

Coronary artery disease（CAD）has gradually become one of the common diseases in human society, because of changes in diet and lifestyle. The implantation of bare metal stents（BMS）and drug eluting stents（DES）is the main method of treating CAD. However, BMS has in-stent restenosis（ISR）in the early stage of implantation. DES also found late stent thrombosis（LST）formation in the late stage of implantation. Re-endothelialization after stent implantation is the key to solving these problems. Recent studies showed that copper ions（Cu2+）could promote the growth of vascular endothelial cells. Therefore, in this study, Cu47Zr42Al7Ti4 and Zr60Cu25Al10Ni5 thin film metallic glass (TFMG) are coated on 316L stainless steel (316L SS) by magnetron sputtering. The characterization of both Cu47Zr42Al7Ti4 and Zr60Cu25Al10Ni5 TFMG-coated 316L SS are evaluated. The results show that Cu47Zr42Al7Ti4 and Zr60Cu25Al10Ni5 TFMG coated on 316L SS can reduce surface roughness and water contact angle. Moreover, it can release trace copper ions to improve the adhesion and proliferation of human umbilical vein endothelial cells (HUVECs).
In the oxidative stress tolerance test, the results reveals that Cu47Zr42Al7Ti4 TFMG-coated 316L SS can improve inflammation and apoptosis level of HUVECs. The results of study demonstrated that Cu47Zr42Al7Ti4 and Zr60Cu25Al10Ni5 TFMG-coated 316L SS can promote the adhesion and growth of HUVECs compared with 316L SS (without coating). Moreover, Cu47Zr42Al7Ti4 TFMG-coated 316L SS can improve the tolerance of HUVECs under oxidative stress. Cu47Zr42Al7Ti4 and Zr60Cu25Al10Ni5 TFMG may have the potential application in coronary stent coating and improve ISR and LST.

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