簡易檢索 / 詳目顯示

研究生: Sintayehu Assefa Endaylalu
Sintayehu Assefa Endaylalu
論文名稱: 三角形結構引致之聲射流與其對微流道混合表現之增益
Enhancement of Mixing Performance in Microchannel with Acoustic Streaming Induced by Triangular Structure
指導教授: 田維欣
Wei-Hsin Tien
口試委員: 陳品銓
Pin-Chuan Chen
曾修暘
Hsiu-Yang Tseng
田維欣
Wei-Hsin Tien
周鼎贏
Dean Chou
莊程媐
Cheng-Hsi Chuang
學位類別: 博士
Doctor
系所名稱: 工程學院 - 機械工程系
Department of Mechanical Engineering
論文出版年: 2022
畢業學年度: 110
語文別: 英文
論文頁數: 114
中文關鍵詞: 聲射流聲射微流體計算流體力學微流體微混合器微粒影像測速儀
外文關鍵詞: acoustic streaming, acoustofluidics, computational fluid dynamics, microfluidics, micromixer, micro-particle image velocimetry
相關次數: 點閱:375下載:8
分享至:
查詢本校圖書館目錄 查詢臺灣博碩士論文知識加值系統 勘誤回報

本研究探討了微流道在匯流處(junction)和流道側壁加入三角形結構引致之聲射流(Acoustic Streaming, AS)對其混合性能之增益。聲射流在T 和 Y 型微流道之匯流處和出口側壁處產生,並以微粒影像測速儀(Micro Particle Image Velocimetry, μPIV)量測在不同的三角形頂角、振幅、振盪頻率和流速下研究了由交界處的中心三角形結構引起的射流流動模式。混合之過程則使用綠色螢光染料溶液和去離子水加以模擬,並透過分析拍攝之螢光強度影像以混合度(degree of mixing) M為性能指標進行量化分析。實驗結果表明,T型微流道在流道位置y=2.15mm處的混合性能因聲射流而得到了增強,混合度M_T從0.4017提高到0.769。聲射流的性能增益在較低流速、較尖銳頂角和較高振幅下具有更好的表現,使 M_T分別從0.369上升到0.769、0.31 到0.530 和0.394到0.652。聲射流的效果進一步透過二維的數值模擬進行研究,數值模型使用了 Navier-Stokes方程式和對流擴散方程式來探討Y型微混合器中多種不同的三角形結構放置位置之配置。模擬結果顯示,在匯流區使用單個三角形結構產生聲射流可將混合度M_Y從0.6642提高到0.8355,而在匯流區與側壁使用三個三角形結構可進一步提高M_Y到0.9981。最後,以實驗驗證了模擬的結果顯示,分別使用單個和三個三角形結構組合,在 2µL/min 入口流速、13kHz 和 33V 振幅下,產生之聲射流可使M_Y由0.380提高到0.7322 和0.894。在這些實驗案例中,不同的輸入參數,如流體流速、振幅功率、三角形頂角等都會影響流動模式和混合性能,而在 y = 2.15mm處的混合度M_Y在入口流速從 1 增加到 8.5µL/min 時從 0.901 逐漸減小到 0.465,隨著幅度從50V減小到10V 時則從0.925 減少到0.444。而當中心單一三角形結構之頂角從〖30〗^o增加到〖82.37〗^o 時,以入口流速3.5µL/min,輸入電壓33V,頻率13kHz的條件下M_Y則從0.570減小到0.365。這些結果說明加入匯流區單一三角形結構對於聲射流引致之匯流微混合器之混合性能能夠有效提升,且與邊壁三角形結構能夠相互提升其效能。


In this study, the mixing performance of microchannel with acoustic streaming was investigated by inducing triangular structures at the junction and channel walls. The acoustic streaming was generated in both T and Y- microchannels at the junction and outlet sidewalls. Experimentally, the acoustic streaming flow patterns induced by a central triangular structure at the junction were first investigated using micro-particle image velocimetry (µPIV) in different triangle top vertex angles, amplitude, oscillation frequency and flow rate. The mixing process was studied using fluorescent green dye solution and de-ionized water, and the degree of mixing was quantified by introducing the standard deviation. The experimental results indicate that a mixing performance was enhanced for the T-junction microchannel at flow length y = 2.15mm, and "M" _"T" was improved by acoustic streaming from 0.4017 to 0.769. Acoustic streaming had a better impact at the low flow rate, sharp vertex angle, and high amplitude, resulting in M_T decreasing from 0.769 to 0.369, 0.530 to 0.31, and 0.652 to 0.394, respectively. The acoustic streaming was then created through 2-D numerical simulation with a model that utilizes Navier-Stokes equations in conjunction with convection-diffusion equations to study more configurations of the triangular structure’s placement positions in a Y-junction micromixer. The simulation results show that the application of acoustic streaming can improve "M" _"Y" from 0.6642 to 0.8355 using a single triangular structure in the junction region, and further improved to 0.9981 with three triangular structures on the junction and side walls. Finally, the simulation results were verified by experiments. It shows that "M" _"Y" improved with acoustic streaming from 0.380 to 0.7322 and 0.894 at 2µL/min inlet flow rate, 13kHz, and 33V amplitude using single and three triangular structure combination, respectively. Throughout all studies, different input parameters such as fluid flow rate, amplitude power, triangle vertex angle, and others influence the streaming flow patterns and the mixing performances. The degree of mixing "M" _"Y" at y = 2.15mm gradually decreased from 0.901 to 0.465 when the inlet flow rate increased from 1 to 8.5µL/min, and from 0.925 to 0.444 as the amplitude reduced from 50V to 10V, respectively. Similarly, "M" _"Y" decreased from 0.570 to 0.365 when the vertex angle of the central single junction triangle increased from 〖30〗^o to 〖82.37〗^oat 3.5µL/min inlet flow rate, 33V amplitude and 13kHz frequency.

Abstract iii Acknowledgements iv Table of Content v List of Figures vii List of Tables xii List of Symbols xiii 1.Introduction 1 1.1 Back ground of the study 1 1.2 Literature Reviews 3 1.2.1 Acoustic streaming and its classification 3 1.2.2 Types of micromixers 8 1.2.3 Mixing Performance of micromixers 11 1.3 Objectives 15 1.4 Thesis structure 16 2. Materials and Methods 17 2.1 Experimental methods 17 2.1.1 Microchannel manufacturing process 17 2.1.2 Experimental materials and apparatus 20 2.1.3 Experimental test procedure 23 2.2 Numerical method 25 2.2.1 Numerical model and parameters 25 2.2.2 Governing equations and boundary conditions 26 3. Mixing enhancement in T-junction microchannel with induced triangle structure and acoustic streaming 29 3.1 Concept of T-junction microchannel including triangular structure 29 3.2 Testing parameters 30 3.3 Data processing 30 3.3 Acoustic streaming 31 3.3.1 Thermal analysis of piezo disc 31 3.3.2 Flow visualization and acoustic streaming 33 3.4 Mixing performance 40 4. A numerical investigation of the mixing performance in a Y-junction microchannel induced by acoustic streaming 46 4.1 Concept of Y- microchannel configuration 46 4.2 Mesh independence test 49 4.3 Acoustic streaming 50 4.4 Mixing performance 55 5. An experimental investigation of the Y-junction microchannel mixing performance induced by acoustic streaming 63 5.1 Testing parameters 63 5.2 Experimental data processing 64 5.2 Acoustic streaming in Y-microchannel 64 5.3 Mixing performance of Y-microchannel 76 5.4 Discussion 86 6. Conclusion and future work 90 6.1 Conclusion 90 6.2 Future work 93 Reference 94

Reference
1.Antognoli, M., et al., Optimized design of obstacle sequences for microfluidic mixing in an inertial regime. Lab on a Chip, 2021. 21(20): p. 3910-3923.
2.Alam, A., A. Afzal, and K.-Y. Kim, Mixing performance of a planar micromixer with circular obstructions in a curved microchannel. Chemical Engineering Research and Design, 2014. 92(3): p. 423-434.
3.Matsunaga, T. and K. Nishino, Swirl-inducing inlet for passive micromixers. RSC Advances, 2014. 4(2): p. 824-829.
4.Xia, Q. and S. Zhong, Liquid mixing enhanced by pulse width modulation in a Y-shaped jet configuration. Fluid Dynamics Research, 2013. 45(2): p. 025504.
5.Hejazian, M. and N.-T. Nguyen, A Rapid Magnetofluidic Micromixer Using Diluted Ferrofluid. Micromachines, 2017. 8(2): p. 37.
6.Usefian, A. and M. Bayareh, Numerical and experimental study on mixing performance of a novel electro-osmotic micro-mixer. Meccanica, 2019. 54(8): p. 1149-1162.
7.Luong, T.-D., V.-N. Phan, and N.-T. Nguyen, High-throughput micromixers based on acoustic streaming induced by surface acoustic wave. Microfluidics and Nanofluidics, 2011. 10(3): p. 619-625.
8.Hao, N.J., et al., Acoustofluidics-Assisted Fluorescence-SERS Bimodal Biosensors. Small, 2020. 16(48): p. 11.
9.Ozcelik, A. and Z. Aslan, A practical microfluidic pump enabled by acoustofluidics and 3D printing. Microfluidics and Nanofluidics, 2021. 25(1): p. 10.
10.Gelin, P., et al., Study on the mixing and migration behavior of micron-size particles in acoustofluidics. Chemical Engineering Journal, 2019. 369: p. 370-375.
11.Lim, H., et al., Acoustic mixing in a dome-shaped chamber-based SAW (DC-SAW) device. Lab on a Chip, 2020. 20(1): p. 120-125.
12.Zhang, C., et al., Acoustic streaming near a sharp structure and its mixing performance characterization. Microfluidics and Nanofluidics, 2019. 23(9): p. 104.
13.Ozcelik, A., et al., An Acoustofluidic Micromixer via Bubble Inception and Cavitation from Microchannel Sidewalls. Analytical Chemistry, 2014. 86(10): p. 5083-5088.
14.Bach, J.S. and H.J.P.R.L. Bruus, Suppression of acoustic streaming in shape-optimized channels. Physical Review Letters, 2020. 124(21): p. 214501.
15.Marmottant, P., et al., Microfluidics with ultrasound-driven bubbles. Journal of Fluid Mechanics, 2006. 568: p. 109-118.
16.Lutz, B.R., J. Chen, and D.T.J.P.o.F. Schwartz, Microscopic steady streaming eddies created around short cylinders in a channel: Flow visualization and Stokes layer scaling. 2005. 17(2): p. 023601.
17.Muller, P.B., et al., Ultrasound-induced acoustophoretic motion of microparticles in three dimensions. Physical Review E, 2013. 88(2): p. 023006.
18.Bruus, H., Theoretical microfluidics. Vol. 18. 2008: Oxford university press Oxford.
19.Ovchinnikov, M., J. Zhou, and S. Yalamanchili, Acoustic streaming of a sharp edge. The Journal of the Acoustical Society of America, 2014. 136(1): p. 22-29.
20.Liou, Y.-S., X.-J. Kang, and W.-H. Tien, Particle aggregation and flow patterns induced by ultrasonic standing wave and acoustic streaming: An experimental study by PIV and PTV. Experimental Thermal and Fluid Science, 2019. 106: p. 78-86.
21.Nama, N., et al., Numerical study of acoustophoretic motion of particles in a PDMS microchannel driven by surface acoustic waves. Lab on a Chip, 2015. 15(12): p. 2700-2709.
22.Zhang, C., et al., Unveiling of the mechanisms of acoustic streaming induced by sharp edges. Physical Review E, 2020. 102(4): p. 043110.
23.Lee, S.H., et al., Effective mixing in a microfluidic chip using magnetic particles. Lab on a Chip, 2009. 9(3): p. 479-482.
24.Wang, S.S., et al., Acoustically induced bubbles in a microfluidic channel for mixing enhancement. Microfluidics and Nanofluidics, 2009. 6(6): p. 847-852.
25.Wu, Z., N.-T. Nguyen, and X. Huang, Nonlinear diffusive mixing in microchannels: theory and experiments. Journal of Micromechanics and Microengineering, 2004. 14(4): p. 604-611.
26.Sahu, P.K., A. Golia, and A.K. Sen, Investigations into mixing of fluids in microchannels with lateral obstructions. Microsystem Technologies, 2013. 19(4): p. 493-501.
27.Shah, I., et al., Experimental and numerical analysis of Y-shaped split and recombination micro-mixer with different mixing units. Chemical Engineering Journal, 2019. 358: p. 691-706.
28.Lee, C., Optimum design of a y-channel micromixer for enhanced mixing according to the configuration of obstacles. Advances and Applications in Fluid Mechanics, 2016. 19: p. 1-22.
29.Wang, C.-T. and Y.-C. Hu, Mixing of Liquids Using Obstacles in Y-Type Microchannels. Tamkang Journal of Science and Engineering, 2010. 13: p. 385-394.
30.Wang, L., S. Ma, and X. Han, Micromixing enhancement in a novel passive mixer with symmetrical cylindrical grooves. Asia-Pacific Journal of Chemical Engineering, 2015. 10(2): p. 201-209.
31.Kandlikar, S.G., Heat transfer and fluid flow in minichannels and microchannels. Vol. pp. 450. 2006, Amsterdam, The Netherlands: Elsevier B.V.
32.Caprini, D., et al., A T-junction device allowing for two simultaneous orthogonal views: application to bubble formation and break-up. Microfluidics and Nanofluidics, 2018. 22(8): p. 85.
33.Hsieh, S.-S., J.-W. Lin, and J.-H. Chen, Mixing efficiency of Y-type micromixers with different angles. International Journal of Heat and Fluid Flow, 2013. 44: p. 130-139.
34.Garstecki, P., et al., Formation of droplets and bubbles in a microfluidic T-junction-scaling and mechanism of break-up. Lab Chip, 2006. 6(3): p. 437-46.
35.Hu, Y., et al., Millisecond mixing of liquids using a novel jet nozzle. Chemical Engineering Science, 2009. 64(5): p. 812-820.
36.Srinivasan, B., et al. Performance evaluation of a pneumatic-based micromixer for bioconjugation reaction. in 2010 IEEE 5th International Conference on Nano/Micro Engineered and Molecular Systems. 2010. Xiamen, China IEEE.
37.Hoffmann, M., M. Schlüter, and N. Räbiger, Experimental investigation of liquid–liquid mixing in T-shaped micro-mixers using μ-LIF and μ-PIV. Chemical Engineering Science, 2006. 61(9): p. 2968-2976.
38.Engler, M., et al., Numerical and experimental investigations on liquid mixing in static micromixers. Chemical Engineering Journal, 2004. 101(1): p. 315-322.
39.Lighthill, S.J., Acoustic streaming. Journal of Sound and Vibration, 1978. 61(3): p. 391-418.
40.Boluriaan, S. and P.J. Morris, Acoustic Streaming: From Rayleigh to Today. International Journal of Aeroacoustics, 2003. 2(3): p. 255-292.
41.Enflo, B.O. and C.M. Hedberg, Theory of Nonlinear Acoustics in Fluids. 2002: Springer, Dordrecht.
42.Tang, Q., et al., On-chip simultaneous rotation of large-scale cells by acoustically oscillating bubble array. Biomedical Microdevices, 2020. 22(1): p. 1-11.
43.Manasseh, R., Acoustic Bubbles, Acoustic Streaming, and Cavitation Microstreaming, in Handbook of Ultrasonics and Sonochemistry. 2016, Springer Singapore: Singapore. p. 33-68.
44.Lutz, B.R., J. Chen, and D.T. Schwartz, Microscopic steady streaming eddies created around short cylinders in a channel: Flow visualization and Stokes layer scaling. Physics of Fluids, 2005. 17: p. 023601.
45.Simon, G., et al., Particle separation in surface acoustic wave microfluidic devices using reprogrammable, pseudo-standing waves. Applied Physics Letters, 2018. 113(4): p. 044101.
46.Nyborg, W.L., Acoustic Streaming near a Boundary. The Journal of the Acoustical Society of America, 1958. 30(4): p. 329-339.
47.Lei, J., et al., Effects of micron scale surface profiles on acoustic streaming. Microfluidics and Nanofluidics, 2018. 22(12): p. 140.
48.Rayleigh, L., On the circulation of air observed in Kundt's tubes, and on some allied acoustical problems. Philosophical Transactions of the Royal Society of London, 1884. 175: p. 1-21.
49.Muller, P.B., et al., A numerical study of microparticle acoustophoresis driven by acoustic radiation forces and streaming-induced drag forces. Lab on a Chip, 2012. 12(22): p. 4617-4627.
50.Eckart, C., Vortices and Streams Caused by Sound Waves. Physical Review, 1948. 73(1): p. 68-76.
51.Wiklund, M., R. Green, and M. Ohlin, Acoustofluidics 14: Applications of acoustic streaming in microfluidic devices. Lab on a Chip, 2012. 12(14): p. 2438-2451.
52.Liu, X. and J. Wu, Acoustic microstreaming around an isolated encapsulated microbubble. The Journal of the Acoustical Society of America, 2009. 125(3): p. 1319-1330.
53.Wu, J. and G. Du, Streaming generated by a bubble in an ultrasound field. The Journal of the Acoustical Society of America, 1997. 101(4): p. 1899-1907.
54.Elder, S.A., Cavitation Microstreaming. The Journal of the Acoustical Society of America, 1959. 31(1): p. 54-64.
55.Huang, P.H., et al., An acoustofluidic micromixer based on oscillating sidewall sharp-edges. Lab Chip, 2013. 13(19): p. 3847-52.
56.Wang, S., et al., Piezoelectric Microchip for Cell Lysis through Cell–Microparticle Collision within a Microdroplet Driven by Surface Acoustic Wave Oscillation. Small, 2019. 15(9): p. 1804593.
57.Rodaree, K., et al., DNA hybridization enhancement using piezoelectric microagitation through a liquid coupling medium. Lab on a chip, 2011. 11: p. 1059-64.
58.Guo, F., et al., Probing cell–cell communication with microfluidic devices. Lab on a Chip, 2013. 13(16): p. 3152-3162.
59.Rasouli, M.R. and M. Tabrizian, An ultra-rapid acoustic micromixer for synthesis of organic nanoparticles. Lab on a Chip, 2019. 19(19): p. 3316-3325.
60.Legay, M., et al., Improvement of heat transfer by means of ultrasound: Application to a double-tube heat exchanger. Ultrasonics Sonochemistry, 2012. 19(6): p. 1194-1200.
61.Zheng, T., et al., Ultrafast crystallization hollow nanocrystals of the resorcinarene hexamer in microfluidic via standing surface acoustic waves (SSAWs). Materials Letters, 2020. 263: p. 127274.
62.Vuillermet, G., et al., Chladni Patterns in a Liquid at Microscale. Physical Review Letters, 2016. 116(18): p. 184501.
63.Yiannacou, K. and V. Sariola, Controlled manipulation and active sorting of particles inside microfluidic chips using bulk acoustic waves and machine learning. Langmuir, 2021. 37(14): p. 4192-4199.
64.Bayareh, M., M.N. Ashani, and A. Usefian, Active and passive micromixers: A comprehensive review. Chemical Engineering and Processing - Process Intensification, 2020. 147: p. 107771.
65.Ansari, M., et al., A novel passive micromixer based on unbalanced splits and collisions of fluid streams. Journal of Micromechanics and Microengineering, 2010. 20: p. 055007.
66.Antognoli, M., et al., Optimized design of obstacle sequences for microfluidic mixing in an inertial regime. Lab on a Chip, 2021.
67.Afzal, A. and K.-Y. Kim, Convergent–divergent micromixer coupled with pulsatile flow. Sensors and Actuators B: Chemical, 2015. 211: p. 198-205.
68.Tsai, C.-H. and X.-Y. Lin, Experimental Study on Microfluidic Mixing with Different Zigzag Angles. Micromachines, 2019. 10: p. 583.
69.Thanjavur Kumar, D., et al., Electric field-induced instabilities in ferrofluid microflows. Microfluidics and Nanofluidics, 2015. 19(1): p. 43-52.
70.Yan, D., et al., Enhancement of electrokinetically driven microfluidic T-mixer using frequency modulated electric field and channel geometry effects. ELECTROPHORESIS, 2009. 30(18): p. 3144-3152.
71.Nouri, D., A. Zabihi-Hesari, and M. Passandideh-Fard, Rapid mixing in micromixers using magnetic field. Sensors and Actuators A: Physical, 2017. 255: p. 79-86.
72.Ahmed, D., et al., A millisecond micromixer via single-bubble-based acoustic streaming. Lab on a Chip, 2009. 9(18): p. 2738-2741.
73.Wong, S.H., M.C. Ward, and C.W. Wharton, Micro T-mixer as a rapid mixing micromixer. Sensors and Actuators B: Chemical, 2004. 100(3): p. 359-379.
74.Rafeie, M., et al., An easily fabricated three-dimensional threaded lemniscate-shaped micromixer for a wide range of flow rates. Biomicrofluidics, 2017. 11(1): p. 014108.
75.Liu, R.H., et al., Passive Mixing in a Three-Dimensional Serpentine Microchannel. Microelectromechanical Systems, Journal of, 2000. 9: p. 190-197.
76.Li, Y., et al., A microsecond microfluidic mixer for characterizing fast biochemical reactions. Talanta, 2012. 88: p. 175-180.
77.Johnson, T.J., D. Ross, and L.E. Locascio, Rapid microfluidic mixing. Analytical chemistry, 2002. 74(1): p. 45-51.
78.Mahmud, F. and K.F. Tamrin, Method for determining mixing index in microfluidics by RGB color model. Asia-Pacific Journal of Chemical Engineering, 2020. 15(2): p. e2407.
79.Boss, J. and W. Poland, Evaluation of the homogeneity degree of a mixture. Bulk Solids Handling, 1986. 6(6): p. 1207-1215.
80.Zhendong, L., et al., Mixing characterization and scaling-up analysis of asymmetrical T-shaped micromixer: Experiment and CFD simulation. Chemical Engineering Journal, 2012. 181-182: p. 597-606.
81.Baek, D., et al., Lithography Technology for Micro- and Nanofabrication, in Nanotechnology for Bioapplications. 2021, Springer Singapore. p. 217-233.
82.Xia, Y. and G.M. Whitesides, SOFT LITHOGRAPHY. Annual Review of Materials Science, 1998. 28(1): p. 153-184.
83.COMSOL Multiphysics 5.6. 2021 [cited 2021 23,9]; Available from: www.comsol.com.
84.CRCnetBASE Product, Handbook of Chemistry and Physics. 97 ed. 2016-2017, Boca Raton, FL, USA: CRC Press
85. Bruus, H., Acoustofluidics 2: Perturbation theory and ultrasound resonance modes. Lab on a Chip, 2012. 12(1): p. 20-28.
86. Friend, J. and L.Y. Yeo, Microscale acoustofluidics: Microfluidics driven via acoustics and ultrasonics. Reviews of Modern Physics, 2011. 83(2): p. 647-704.
87. Westerweel, J., P.F. Geelhoed, and R. Lindken, Single-pixel resolution ensemble correlation for micro-PIV applications. Experiments in Fluids, 2004. 37(3): p. 375-384.
88.Jordan, T., et al., Electrical Properties and Power Considerations of a Piezoelectric Actuator. MRS Proceedings, 2000. 604.

QR CODE