隨著人口老化問題，台灣之洗腎人口有逐年往上攀升之趨勢，其中腎衰竭患者選用腹膜透析比例由逐年增加之趨勢，而目前腹膜透析中電解液聚氯乙烯袋，僅能依賴國外進口，台灣並無法生產。傳統製程上，為了讓塑膠材料具彈性及柔軟，產業上常使用磷苯二甲酸酯類之塑化劑，且對於聚氯乙烯而言，添加量更要高達到重量比例30%至50%，才能讓原本性質剛硬聚氯乙烯軟化，且塑化劑亦可能從高分子基材外移於電解液中，可能危害腎臟病患病情。因此本研究將先選用僅含碳氫原子之聚丙烯為基材，探討不同異構性之聚丙烯高分子添加塑化劑後，聚丙烯之材料特性以及塑化劑遷移之程度。由紅外線光譜結果顯示添加塑化劑後聚氯乙烯明顯出現一羰基峰為鄰苯二甲酸酯官能基，在熱重分析結果中高分子量全同立構聚丙烯有一明顯轉折點落於68%，此與配置之聚丙烯/磷苯二甲酸酯高分子樣品濃度相當，紫外線光譜結果顯示同溫度下塑化劑遷移程度之比較，低分子量全同立構聚丙烯最高、低分子量不定形聚丙烯次之、高分子量全同立構聚丙烯最低，此結果與液相層析質譜儀所分析相似，以塑化劑遷移程度比較顯示出高分子量全同立構聚丙烯混參塑化劑後，塑化劑能較穩定留在於高分子基材內。
為了將聚己內酯(PCL)應用作為生物可降解性的腸胃道植入物，我們研究具生物可降解性的聚己內酯在生物體內的降解行為，以溶劑澆鑄的方式製造聚己內酯膜以及選擇Sprague Dawley大鼠作為生物模型，藉由手術將聚己內酯分別放入胃部以及腸道。掃描式電子顯微鏡結果顯示放置於胃中的聚己內酯表面呈現全面性的糜爛，而放置於腸道中的聚己內酯則是局部性侵蝕；使用示差掃描量熱分析及膠體滲透層析儀辨別分子量及結晶度降低與聚己內酯膜降解行為的關係，聚己內酯膜的降解在有含有酶情況下是不同於水解降解，透過重量損失分析可知道置於腸道中聚己內酯的降解速率比置於胃中聚己內酯的降解速率快。

Chronic kidney disease is a large and growing problem among aging populations in Taiwan. Peritoneal dialysis (PD) is one of treatment for patients with chronic kidney disease worldwide. However, the currently dialysis bag used in peritoneal dialysis, which was made form polyvinyl chloride (PVC) blended with plasticizers. The plasticizer might be migrated from aqueous fluid and accumulated in the patient. In this project, two tacticity polypropylenes were selected instead of PVC materials for investigating the migration of plasticizer from polymer. Plasticizer, Bis(2-ethylhexyl) phthalate (DEHP), blended with isotactic and atactic polypropylene and then immersed in hot and room temperature water to study the migration of plasticizer. FT-IR result showed that the carbonyl band from DEHP exhibited in polypropylene blended samples indicated that DEHP was successfully mixed with polypropylene. From thermal gravimetric analysis, the results indicated that 32% of DEHP blended in high-molecular isotactic PP. From UV results, it also indicate that the amount of DEHP migrated from low-molecular isotactic PP more than that of low-molecular atactic PP and high-molecular isotactic PP. In conclusion, high-molecular isotactic polymer will be recommended as packing material due to low migration amount of DEHP in water.
To realize the biodegradable properties of poly(ε-caprolactone) (PCL) gastrointestinal tract, the PCL films was separately implanted in stomach and intestine of rat. The PCL films was prepared from solvent casting in this study. The various PCL films were surgically implanted in Sprague Dawley rats for one month and then the biodegraded PCL films were took out for further analysis. Through weight-loss analysis of implanted PCL film at different time period, the degradation rate of PCL implanted in intestine faster than the degradation rate of PCL implanted in stomach. In addition, scanning electron microscopy results showed that the surface of PCL films implanted in stomach is rough, however the surface of PCL films implanted in intestine exhibited partial erosion. The effects of molecular weight and degree of crystallinity on the degraded PCL film were also evaluated by differential scanning calorimetry and Gel Permeation Chromatography. In stomach, since there is lack of enzyme, the degradation of PCL film was dominantly in hydrolysis process. However, the degradation of PCL film in intestine involved both hydrolysis and enzymatic process. From the analysis of molecule weight in biodegraded PCL films, the enzymatic degradation of PCL film is different from the hydrolysis degradation of PCL films.

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