第一部分：我們使用殼層成長摻雜法(shell growth doping)成功地將Mn、Co、Ni等三種過渡金屬分別摻雜於CuInS2/ZnS核殼結構量子點中，並以不同摻雜量作為主要的參數調整，接著利用TEM、XRD、UV、PL、EPR與SQUID來進行摻雜量子點的組成、結構、光學性質與磁性分析。從中可以發現Mn與Ni確實是以摻雜的方式與CuInS2/ZnS量子點結合並展現出順磁特性與新的發光機制；而Co則是與CuInS2/ZnS形成合金量子點，此量子點隨著Co含量的增加可將其發光顏色從橘黃光調控制綠光並於室溫下顯現出順磁特性。

第二部分：以摻雜量子點作為基礎材料，並藉由兩性物質月桂酸的包覆，賦予其表面擁有大量的親水性羧酸基團而能形成溶解度佳且無毒性的水相量子點。接著再利用EDC/ NHS共價交聯系統對水相量子點進行葉酸功能化修飾，使其能與HeLa癌細胞表面的葉酸受之間有良好的親和力。此外，結合量子點優越的發光特性，能成功地製備出具有癌細胞螢光顯影與標靶的雙功能量子點材料。

Part I：In this work, we have used shell growth doping strategy for the synthesis of transition metal ion doped CuInS2/ZnS quantum dots (QDs). CuInS2 QDs was utilized to be a host and followed by depositing thin ZnS shell for the attachment of transition metal ions (such as Mn2+, Ni2+, and Co2+). We report the effect of the different transition metal doped CuInS2/ZnS QDs on the optical properties (such as photoluminescence [PL] quantum yield, PL full width at half-maximum, and wavelength of maximum PL emission) of QDs. The presented materials were characterized by HRTEM, XRD, EPR, and SQUID instruments. Mn and Ni doped QDs can appear paramagnetism property and new luminescence mechanism. Co doped QDs becomed alloyed QDs which can be tuned from orange-yellow light to green light and showed room temperature paramagnetism property.

Part II： We used dodecanoic acid (DDA) capping agent to interdigitate with hydrophobic and protective agents on the surface of different transition metal doped CuInS2/ZnS QDs, that allow phase transfer of hydrophobic QDs from the organic phase into the aqueous phase. To demonstrate their potential biomedical application, the resulting water-soluble QD were further conjugated with folate via EDS/NHS protocol for staining in HeLa cancer cells. Confocal imaging characterization revealed that folate-conjugated QDs could target specifically and effectively HeLa cells via folate receptor-mediated targeted delivery.

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