本論文主要以高溫熱裂解法與熱注射法合成I-III-VI族奈米異質結構材料，且藉由各種不同的實驗參數來控制其晶體尺寸與形狀，期待尺寸與形狀的不同來調控其光學性質，以便於日後應用於太陽能電池領域與醫學影像分析顯影科技。此研究以CuInS2-ZnS異質結構奈米晶體為主體，分為異質結構材料的製備與多重光學標靶顯影兩部分，並且搭配穿透式電子顯微鏡、X光繞射圖譜鑑定其晶體型態以及核磁共振顯影、共軛交顯微鏡進行影像測試。

第一部分: 我們針對點或棒狀的奈米異質結構材料提出一個簡單且容易控制的製備方法，其反應體系以硫化銅當作晶種，經由一步反應而生成各種金屬硫族奈米異質結構材料，包含 Cu2S-ZnS(Cu2S-ZS)、Cu2S-CuInS(Cu2S-CIS) 以及 Cu2S -CuInZnS(Cu2S-CIZS)，並且進行結構、型態與組成之分析。在參數調整方面，我們以改變前驅物比例、反應溫度、殼層前驅物注入之體積與時間來有效控制晶體之生長長度。目前本系統已經能夠成功的控制晶體尺寸於20~200 nm之間。期許未來能在太陽能電池領域有相當的應用。

第二部分:以CuInS2/ZnS異質結構材料為基礎，藉由兩性高分子的包覆，賦予其表面具有大量的親水性羧基以達到水溶性量子點之目的，並且利用碳化二亞胺作為交聯劑對量子點進行表面官能化。在這邊我們利用EDC/NHS交聯系統作為基礎，將量子點同時與釓離子錯合物及葉酸進行結合；其釓離子錯合物為磁性物質，可應用於核磁共振造影，而葉酸為一種靶向性物質，對特定癌細胞具有特殊吸收能力，因此可作為細胞標靶之應用，最後再結合量子點本身優越之螢光性能，成功開發出同時具有癌細胞標靶、細胞螢光影像以及磁振造影三種生醫應用之多功能奈米材料，期許未來在醫學臨床上有更廣泛的應用。

Part I
This research claims a facile syntheses route for I-II-III-VI heterostructures Cu2S-ZnS, Cu2S-CuInS, and Cu2S-CuInZnS in a noncoordinating solvent. We exploit seed-mediated synthesis as a basis of crystal growth. The Cu2S seed and ZnS anisotropic nanorod are prepared by thermal decomposition and hot-injection respectively. By using 1-dodecanethiol as both the reactant for the sulfur source and the capping ligands, with copper acetate as the copper source, we synthesized Cu2S and Cu2S-CuInS seeds in the absence and presence of indium acetate, respectively. In the section of the parameter adjustment, we control the heterostructures aspect ratios by changing different reaction temperature, injection volume, and various annealing time, then successful control of the heterostructures length in a range of 20 nm to 200 nm. In summary, this one-pot two-step approach can be successfully, because both seeds and precursors can be grown controllably in the same reaction vessel, and without intermediate seed purification, yielding easy handling, large-scale production capability, and high synthetic reproducibility. In the future, we hope that these nanoheterostructures will be applied to optoelectronic and photovoltaic.
Part II
This research successfully proposed a reliable method for preparing multifunctional CuInS2 nanoparticle, which be able to applied in fluorescent imaging, magnetic resonance imaging, and tumor-specific targeting. This study is divided into three parts: (1) amphiphilic copolymer, PMAO, was wrapped on the surface of CuInS2 quantum dot to create a large number of carboxyl group, thus not only conferring the QDs water dispersible but also provides useful reactive groups for further functionalization; (2) to integrate the MRI capability of our quantum dot. paramagnetic gadolinium chelates (Gd-DTPA) was further conjugated with carboxy group on the surface of the CuInS2 quantum dots, which is denoted as Gd-CuInS2 quantum dots, by using straightforward EDC/NHS catalyzed coupling reaction. (3) to demonstrate the targeting capability of these newly synthesized quantum dots, we have used folate-receptor targeting by utilizing folic acid to conjugated with the Gd-CuInS2 quantum dots, which is denoted as FA-Gd-CuInS2. Folic acid, a high affinity ligand to floate receptors is efficiently internalized into the cell through the receptor mediated endocytosis even when conjugated with a wide variety of molecules. The results reveal that the FA-Gd-CuInS2 quantum dots show highly effective dual-modality imaging probes for specific cancer diagnosis.

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