本論文利用海藻酸鈉與不同比例的鈣型聚麩胺酸進行離子交聯，最後再輔以氯化鈣架橋劑以形成架橋較完全的水膠，另外，再製備海藻酸鈉-氯化鈣與海藻酸鈉-鈉型聚麩胺酸兩種水膠進行比較。藉由各種血液相容性質分析、保水、PH敏感性等物性試驗，來作為開發生醫材料應用上的價值評估；還有利用壓縮試驗計算交聯密度(νe)，以及利用釋放試驗了解水膠膜的藥物釋放模式。
由實驗結果顯示海藻酸鈉-聚麩胺酸鈣水膠在各性質上均優於海藻酸-氯化鈣水膠與海藻酸鈉-鈉型聚麩胺酸水膠，並具有良好pH敏感性、優異的血小板與蛋白質吸附特性，以及促進凝血的效果。因此我們推測在披覆型生醫材料及藥物釋放的應用，相信具有很大的發展濳力。

In this study, we used calcium form γ-polyglutamic acid in different weight ratio to prepare alginate hydrogels, they also compared with the traditional hydrogels cross-linking with calcium chloride and sodium form γ-polyglutamic acid. Water resistance tests, water vapor transmission test, and other biocompatible tests were employed to confirm the applicability of this hydrogel as a wound converings material. Then, effective cross-linking density (νe) of hydrogel was characterized according to the value of compression modulus (G). Afterwards, these hydrogels were releasing behavior would be observed.
All of our data shows the properties of the alginate- calcium form polyglutamic acid hydrgel better than the traditional alginate-calcium chloride hydrogel and alginate- sodium form polyglutamic acid Beside, our hydrogel not also have pH-sensitive but also have a superiority in platelet adherence ability and acceleration coagulation time. Overall results demonstrated the alginate-polyglutamic acid hydrgel have a potential for wound dressing and drug delivery regions.

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