研究生: |
黃雅萱 Ya-Hsuan Huang |
---|---|
論文名稱: |
生質丁酸生產程序之建模與最適化 Modeling and Optimization of Bio-Butyric Acid Production |
指導教授: |
周宜雄
Yi-Shyong Chou |
口試委員: |
李豪業
Hao-Yeh Lee 王逢盛 Feng-sheng wang |
學位類別: |
碩士 Master |
系所名稱: |
工程學院 - 化學工程系 Department of Chemical Engineering |
論文出版年: | 2014 |
畢業學年度: | 102 |
語文別: | 中文 |
論文頁數: | 103 |
中文關鍵詞: | 丁酸 、建模 、最適化 |
外文關鍵詞: | Modeling, Optimization, Butyric Acid |
相關次數: | 點閱:333 下載:1 |
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在本研究中,使用Clostridium tyrobutyricum的批式醱酵實驗數據,建立非結構化的數學模型來描述細胞生長、產物生成與基質消耗。利用不同基質起始濃度醱酵的實驗數據與模型預測結果,以最小化殘餘誤差加權平方總和(Sun of the Square of Weighted Residues)的方法,來估測模型的所有參數。基於此模型,以產率與生產力最大化為目標,搜尋反應器操作模式與操作變數最適化問題。研究結果,反應器操作模式最適化為連續式模式。決定反應器模式後,針對操作變數進行最適化研究,其中操作變數則包含稀釋速率、醱酵槽分流比、進料流率比、醱酵槽體積比與基質進料濃度。在參數估計與最適化問題研究皆利用基因演算法(Genetic Algorithm)進行搜尋。
In this study, we constructed unstructured models to describe the kinetic of cell growth, product formation, and substrate consumption in the batch fermentation of Clostridium tyrobutyricum. All the parameters in the models were estimated by minimizing the sun of the square of weighted residues (SSWR) between the predictions of the models and the experimental data obtained from batch fermentation with different initial substrate concentrations. Based on this models, the optimal problem of bioreactor operation and operation variable were analyzed by maximizing the yield and productivity. The optimal model of the bioreactor operation is the continuous. The operation variables include the dilution rate, the bleed ratio, the feed flow ratio, the volume ratio, and the feed substrate concentration. The parameter estimation and the optimization problem were determined by Genetic Algorithm (GA).
[中文]
[1] 詹明峰,「生物系統建模、最適化與控制設計」,博士論文,國立台灣科技大學,台北(2012)。
[2] 林勳棟,「整合醱酵與分離程序的最適化設計研究」,博士論文,國立中正大學,嘉義(2008)。
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[英文]
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