當脊髓損傷時，將神經幹細胞移植至損傷部位，能有機會使其分化為神經元並能重建部分神經迴路與功能，由於神經幹細胞本身的分化並不受控制，因此必須藉由外力誘導(例如：磁場)，但磁信號之誘導方式需要將磁性奈米粒子放入生長中的神經幹細胞，再加上外部磁場作用後方能具有效果，但此方磁場法協同機制相對複雜。根據文獻指出氧化鋁與神經前驅幹細胞有生物相容性，而摻雜氧化鋯之生物活性玻璃能促進間質幹細胞增殖，因此本研究提出一種使用噴霧乾燥技術製備之摻雜氧化鋁之生物活性玻璃和摻雜氧化鋯之生物活性玻璃來測試是否對於神經元之分化有顯著效益。
由於噴霧乾燥法與其他常見生物活性玻璃粉末製程方式相比擁有製程溫度較低、粉末純度高、形貌易控制及當日產量較高等優點，因此本研究將神經幹細胞之增值與分化定為首要目標，並於探討氧化鋁摻雜與氧化鋯摻雜之生物活性玻璃之形貌、晶體結構、體外生物活性等特性。

When there is spinal cord injury, transplanting neural stem cells to the injury site holds the potential to induce their differentiation into neurons and facilitate the reconstruction of partial neural circuits and functions. Due to the uncontrolled differentiation of neural stem cells, external forces, such as a magnetic field, are necessary for induction. However, the induction mechanism of magnetic signals is complex and involves incorporating magnetic nanoparticles into growing neural stem cells, followed by the application of an external magnetic field for effectiveness.
According to literature, aluminum oxide exhibits biocompatibility with neural precursor cells, and bioactive glass doped with zirconium oxide promotes the proliferation of mesenchymal stem cells. Therefore, this study proposes the use of bioactive glasses doped with aluminum oxide and zirconium oxide, prepared using spray drying technology, to investigate their potential benefits for the differentiation of neurons.
Due to the advantages of spray drying over other common processes for bioactive glass powder production, including lower processing temperatures, higher powder purity, easy morphology control, and higher daily production yield, this research prioritizes the enhancement and differentiation of neural stem cells. The study will also explore the morphology, crystal structure, and in vitro bioactivity of bioactive glasses doped with aluminum oxide and zirconium oxide.

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