乳癌是危害婦女健康排行第一的惡性腫瘤，發生率為女性癌病之首。文獻指出，直徑1公分以內的早期乳腺癌手術後五年生存率可達90%以上，若能及早發現及早治療，對延續生命有舉足輕重的作用，若能成功開發出操作容易又具有一定準確度的檢測儀器，將能給予患者有利的協助。
本研究對受測者進行心電訊號、動脈血壓波形和雷射都卜勒血流等非侵入式量測，期望可找出由乳癌生長所伴隨的人體循環系統中血管及血流特性的改變，達到乳癌早期偵測與病程監控之目的。
實驗設計上，依照TNM 系統（tumor-node-metastasis），將第三期、第四期乳癌患者定義為A組，第零期、第一期、第二期定義為B組，與健康女性組成之空白組C組進行比較探討，我們針對動脈血壓波形與雷射都卜勒血流訊號進行時域及頻域分析，並觀察使用的循環參數能否有效解析乳癌帶來的差異。
實驗結果發現多項參數都具有顯著的解析能力，也驗證乳癌確實對人體血管型態及血流狀態產生一定程度的改變，未來期望能推廣到其他部位種類的惡性腫瘤，除了早期偵測外，亦能對癌症病程的監控有所解析，落實及早發現及早治療的願景。

Breast cancer is the most dangerous cancer in women, the incidence ranked first. Some literature shows that early breast cancer which size less than 1 cm, the 5-year relative survival rate is up to 90%. Therefore, early detection of breast cancer plays an important role in treating. If we can construct a convenient detection system, it will be able to assist patients a lot.
In this study, we applied circulatory signal analysis including ECG, blood-pressure waveform measurement system and commercial laser doppler flowmetry to measure circulatory parameters in breast cancer patients. We hope to find out the difference about blood vessels as well as blood flow between breast cancer subjects and health female.
Experimental design defines right side of healthy females as control group. Cancer patients are defined as “group A” or “group B” by TNM staging system(tumor-node-metastasis). We focused on the arterial blood pressure waveform and laser Doppler blood flow signals in the time domain and frequency domain analysis, and observe the use of circulatory parameters can effectively resolve the differences in breast cancer.
It was found that a number of parameters have significant differences, but also verify the change in blood vessels and blood flow caused by the breast cancer growing. In the near future, we expect that our early detection system can extend to other types of cancer. In addition to early detection, but also can monitor the progress of cancer, and achieve the goal of early treatment.

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