目前的糖尿病治療方法多透過外科手術來治療病態性肥胖的糖尿症患者，透過減少腸道養分吸收來達到控制血糖的效果，目的在於改變消化道結構以影響胃腸道的運作方式，然而手術治療所衍伸的副作用通常是不可逆的，因此開發出非侵入性的植入物來治療二型糖尿病。本研究利用聚偏氟二乙烯壓電薄膜製成的高分子腸套管，植入二型糖尿病大鼠的十二指腸端，改善其血糖及體重，進而達到治療肥胖及二型糖尿病的效果，聚偏二氟乙烯為一種優良的生醫材料，其具有良好的機械性質、生物相容性及化學穩定性，為評估壓電性薄膜對於胃腸道的影響，本研究分別使用兩種不同製程的PVDF薄膜植入二型糖尿病大鼠的為腸道內，分別使用溶劑流延法及縱向拉伸製程(MDO)來進行製備，這兩種製程所產出的PVDF薄膜分別在機械強度、結晶相的組成、壓電性能有不同的差異，MDO製程的薄膜與溶劑流延法的薄膜相比擁有較高的機械強度，透過FTIR、Raman及XRD可以判斷薄膜的結晶相組成，從數據上可判斷MDO製程的薄膜由較多的β相所組成，而β相的多寡則影響到薄膜的壓電性能，因此MDO製程的PVDF薄膜可以產生較高的電壓，從大鼠動物實驗的結果可以判斷，安裝薄膜的組別在體重及血糖控制上得到極大的改善，兩種安裝薄膜的組別在血糖和體重上則沒有太大的差異。

Current diabetes treatments are usually used the surgery to treat morbidly obese diabetics.　The manipulation of blood glucose of surgical treatment is from the reducing intestinal nutrient absorption,　however the drawback would be altered the structure of the digestive tract.　In addition, the side effects of surgical treatment are usually irreversible.　Moreover, non-invasive implants have been proved can be used to treat type 2 diabetes. The purpose of this study was for preparation of piezoelectric polymeric tube from polyvinylidene fluoride (PVDF) and then implanted in the duodenal barrier in the intestine for controling the blood sugar and body weight for type 2 diabetic rats. Polyvinylidene fluoride is an excellent biomedical material from its inert properties, and it also has good mechanical properties, biocompatibility and chemical stability. To evaluate the piezoelectric effect of PVDF in the treatment of type 2 diabetic rats, we prepared two PVDF membranes for implantation in the intestine of obesity and type 2 diabetes. The first PVDF film is prepared by the solvent casting method. The second PVDF film is prepared by machine direction orientation (MDO). The mechanical strength, phase composition and piezoelectric properties of PVDF film varied with of film formation process. PVDF films prepared from MDO process have higher mechanical strength than the film prepared from solvent casting. The composition of crystal phases from PVDF films have benn judged by FTIR, Raman spectroscopy and XRD. The results show that the film prepared by the MDO process has more β phase than the film prepared from solvent casting method. Piezoelectric properties are related to the contents of the beta phase, which mean that the high beta phase content generated higher voltages. The body weight and blood glucose of type II diabetes rats has been controlled for the rats implanted with PVDF film in the intestine when compared with unimplanted group. However, there were no significant differences for rats implanted with PVDF films prepared from different processes.

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