自1980年代微通道的概念提出後，微流體控制技術已有長足發展。以混合、換熱、分離和反應為主的微操作單元具有三高(高反應選擇性、高品質、高安全)、三低(低三廢、低爆炸風險、低製造成本)、反應時間短、程序易控制、佔地面積小等優勢，為化工生產發展新的方向。本研究以微反應器系統進行甲基丙烯酸與環氧丙烷開環加成反應，製備甲基丙烯酸羥丙酯，利用微反應器降低製程危險性並發展連續生產製程。
第一階段使用MMRS模組化微反應器系統，以Miprowa微反應器為主體和不同混合的模塊組合而成。以田口實驗法得到最佳的操作條件為：反應溫度為130℃、滯留時間為30 min、環氧丙烷/甲基丙烯酸的莫耳比為 1.1、系統壓力為10 bar，可達成72%以上的甲基丙烯酸轉化率，甲基丙烯酸羥酯選擇率可達90.8%。以氣相層析質譜儀分析產物與副產物，並觀察在微反應器系統中不同操作條件下，對反應的影響以及操作參數限制。
在第二階段中，本研究通過微反應器主體的更換和反應器串聯等的不同系統設計期望增進效果，以更加瞭解微反應系統在不同製程中系統設計的方式，並確認氣液分離現象對反應的負面影響，進一步對其製程開發的可行性與使用時的安全性進行評估，本研究可作為後續微反應器系統設計與應用的參考依據。

Since the concept of microreactor was reported in the 1980s, the microfluidic control technology has developed rapidly. The micro operation units, including mixer, heat exchanger, separator, and reactor, exhibits these characteristics, three H (high reaction selectivity, high quality, high safety), three L (low three wastes, low explosion risk, low manufacturing cost), short reaction time, easy control of the process, and small floor space, resulting in a new direction for chemical production. In this study, the ring-opening addition reaction of methacrylic acid and propylene oxide was carried out in a microreactor system to synthesize hydroxypropyl methacrylate. The manufacture risk and continuous production process were respectively reduced and developed with applying microreactor.
The MMRS modular microreactor system, including major reactor (Miprowa) and variant mixing modules, was applied in the first part. The optima operating conditions obtained by Taguchi experimental design strategy were: 130°C of reaction temperature, 30 minutes of residence time, 1.1 of molar ratio for PO/MAA, and 10 bar of system pressure, resulting in 72.1% of conversion for MAA and 90.8% of selectivity for HPMA. The product and by product were analyzed by gas chromatography (GC) and gas chromatography mass spectrometer(GC-mass). The effects of operation parameters in the microreactor system were investigated to find out the reaction pathway and limitation of operation parameters.
In the second stage, the variant reactor and connection of reactors in series were further applied to promote reaction rate expectantly. The reaction design was further modified and the design concept for different process was confirmed as well. The negative effect of gas-liquid separation phenomenon was observed in the series reactor. The feasibility and safety design of MRT process were evaluated. This study can be used as a reference basis for design and application of microreactor.

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