本文以N,N-二甲基丙烯醯胺 (dimethylacrylamide, DMA), 甲基丙烯醯氧丙基三(三甲基矽氧烷基)矽烷 (tris-(trimethyl-silyl-propyl-methacrylate), TRIS)，及N-乙烯基咯烷酮 (N-vinylpyrrolidone, NVP) 為單體，再加入PI1173光起始劑以及交聯劑二甲基丙烯酸乙二醇酯 (ethylene glycol dimethylacrylate, EGDMA)，以UV起始法經由自由基共聚合製備DMA-TRIS-NVP矽水膠。 由實驗結果得知，通過調整親水性單體DMA, NVP 及疏水性單體TRIS的比率可改變此矽水膠的含水率與透氧率. 其含水率隨著NVP的增加而上升，而接觸角也因NVP的加入而降低，因而提高水膠的親水性，然而透氧率則相反降低。在機械強力及楊氏係數方面會隨著NVP的增加而有下降的趨勢。 DMA-TRIS-NVP矽水膠的透光率都在可見光範圍可達97%以上。而在蛋白質吸附試驗中，利用BCA蛋白質測定法來探討，結果顯示隨著NVP的含量增加，蛋白質吸附量會明顯上升。在細胞毒性方面，以ISO10993-5的判定上屬於0級，所以其細胞毒性極底。根據以上特性，未來可以利用此矽水膠來作為隱形眼鏡及眼科的材料。

A silicone hydrogel was synthesized through photoinitiated free radical polymerization process using dimethylacrylamide (DMA), tris-(trimethyl-silyl-propyl-methacrylate) (TRIS), N-vinylpyrrolidone (NVP), ethylene glycol dimethylacrylate (EGDMA) as crosslinker and PI1173 as photoinitiator. The equilibriumwater content (EWC) and oxygen permeability was adjustable by changing the ratio between hydrophiclic monomers DMA, NVP and hydrophilic monomer TRIS. The results indicated that higher NVP content led to a higher water content, lower contact angle, lower elastic modulus and higher protein adsorption. In term of oxygen permeability, at an NVP concentration of 25%, the silicone hydrogel sample exhibited a Dk value of 46 barrers. In addition, these silicone hydrogels were confirmed non-cytotoxic according to a in vitro L929 fibroblast assay. In summary, the results illustrated that the DMA-TRIS-NVP copolymer was a good candidate for contact lens material application due to high hydrophilicity, excellent optical transparency, improved oxygen permeability, good wettability and biocompatibility.

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