本研究以聚二甲基矽氧烷(Polydimethylsiloxane, PDMS)作為基材，與異佛爾酮二異氰酸酯(Isophorone diisocyanate, IPDI)及甲基丙烯酸-2-羥基乙酯(2-hydroxy-ethyl methacrylate, HEMA)進行聚合反應，合成PDMS-PU-HEMA矽水膠共聚物，再混摻不同比例之Reactive Yellow 15 (RY15)至PDMS-PU-HEMA矽水膠共聚物，使其形成具有抗藍光功能矽水膠共聚物，以紫外光硬化交聯處理形成RY15之矽水膠隱形眼鏡薄膜(RY15-PDMS-PU-HEMA)，並探討不同混摻比例RY15-PDMS-PU-HEMA之物性分析及生物相容性測試，透過UV-vis量測結果顯示混摻RY15後之RY15-PDMS-PU-HEMA其藍光波段(380-500nm)之透光率降低約26%，具有良好抗藍光效果，於細胞毒性試驗結果顯示細胞相對成長率高達90%，根據上述結果，RY15-PDMS-PU-HEMA經由混摻RY15後，具有良好的抗藍光性、透氧性及親水性，且對於生物細胞不具有毒性，未來對於隱形眼鏡材料的應用具有良好的潛力。

Currently, anti-blue light has been an important issue due to the increasing dependence on 3C electronic products. The aim of this study is to add the function of anti-blue light to silicone based hydrogel contact lens.
In this study, polydimethylsiloxane (PDMS) was used as the base material, reacted with isophorone diisocyanate (IPDI) and 2-hydroxy-ethyl methacrylate (HEMA) to synthesize PDMS-PU-HEMA silicone hydrogel copolymer. Reactive Yellow 15 (RY15) was added in PDMS-PU-HEMA in different proportions to form silicone hydrogel copolymer with the function of anti-blue light. After curing the copolymer with UV light to form RY15 silicone hydrogel contact lens (RY15-PDMS-PU-HEMA). The physical properties and the biocompatibilities of RY15-PDMS-PU-HEMA with different blending ratios of RY15 were investigated.
According to the result of UV-vis absorbance, the blue light band (380-500nm) transmittance was reduced by about 26%, indicating that RY15-PDMS-PU-HEMA exhibited anti-blue light activity. The cytotoxic test results showed that the relative growth rate (RGR) of the cells was as high as 90%.
The overall results demonstrated that after blending with RY15, RY15-PDMS-PU-HEMA exhibited good blue light resistance, oxygen permeability and hydrophilicity, and no toxicity to biological cells. In the future, it has potential for contact lens applications.

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