研究生: |
廖智盛 Zhi-Sheng Liao |
---|---|
論文名稱: |
高度敏感性酸鹼應答型高分子微胞應用於高效抗癌治療及可控制的藥物傳輸 Ultrasensitive pH-Responsive Polymeric Micelles for High-Efficiency Anticancer Therapy and Controllable Drug Delivery |
指導教授: |
鄭智嘉
Chih-Chia Cheng |
口試委員: |
邱信程
Hsin-Cheng Chiu 謝永堂 Yeong-Tarng Shieh 高震宇 Chen-Yu Kao 陳建光 Jem-Kun Chen 蔡協致 Hsieh-Chih Tsai 何郡軒 Jinn-Hsuan Ho 鄭智嘉 Chih-Chia Cheng |
學位類別: |
碩士 Master |
系所名稱: |
應用科技學院 - 應用科技研究所 Graduate Institute of Applied Science and Technology |
論文出版年: | 2017 |
畢業學年度: | 105 |
語文別: | 中文 |
論文頁數: | 106 |
中文關鍵詞: | 高度酸鹼應答 、聚胺酯共聚高分子 、高度微胞穩定性 、藥物釋放 、抗癌治療 |
外文關鍵詞: | Ultrasensitive pH-Responsive, Polyurethane, Highly micelles stability, Drug release, Anti-cancer therapies |
相關次數: | 點閱:265 下載:0 |
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本研究成功合成出具備高度酸鹼應答能力的聚胺酯共聚高分子,此材料不僅能在水溶液中自組裝形成奈米尺寸的微胞,且具有優異的藥物負載能力及可調控的藥物包覆量,於長效測試中亦呈現出高度微胞穩定性。在小鼠巨噬細胞(Raw 264.7)的體外實驗,不僅能成功透過環境酸鹼值控制藥物釋放的行為,更能在微酸環境條件下(pH = 6.0)觀測到藥物胞吞作用(Endocytosis)的過程,證實此材料不僅有極優越的藥物釋放能力,且有機會拓展至人體抗癌治療的發展潛力。
This work has successfully constructed a polyurethane containing Ultrasensitive pH-Responsive ability. The new material can not only perform self-assembly of nano-scale micelles in aqueous solution, but also possess excellent drug-loading capability and adjustable drug-loading capacity. Besides, in the test of a long period of time, the micelles still represent highly durability and stability. In vitro test of the Macrophages (Raw 264.7), the behavior of the drug release can be well controlled by the pH value of the environment. Moreover, under weak acidic conditions (pH = 6.0), endocytosis was observed, which prove that this material not only shows promising drug release ability, but also has potentials in expanding to the anti-cancer therapies in human bodies.
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