由於近年來光電工業的進步，加上糖尿病患者逐漸年輕化，使得許多人對於葡萄糖的檢測再度產生了興趣，光學生醫感測器在這方面具有相當大的淺力，使得患者能藉由每天很便利的進行葡萄糖檢測來改善糖尿病患著的生活，而 SPR 干涉系統在生物醫學的檢測上面逐漸取代傳統的方法，更是被廣泛的應用在各種疾病的感測，因為它有著對不同折射率的待測物有高靈敏度的檢測特性。
表面電漿共振(Surface Plasmon Resonance, SPR)是由橫向磁場 TM 模態漸逝波與表面電漿波共振吸收變化進行感測，SPR 通常具有三種不同的結構以獲得表面電漿耦合，分別是棱鏡耦合、光柵耦合以及波導耦合。本篇論文則是使用棱鏡耦合搭配相位調製的方法來做為量測主軸，由於在固定角度或共振波長時，利用相位去觀察變化是最為明顯的。
由於我們實驗室的 1310nm 掃頻雷射的解析度高達 3pm，比起我們的 OSA 解析度 10pm 來的更好。所以我們嘗試利用掃頻雷射來做為實驗主題，嘗試是否能對生醫感測提高靈敏度，因為寬頻譜光源干涉長度較短，而掃頻雷射干涉長度來的較長，所以相對容易發生干涉，但在實驗過程中，我們發現有嚴重的 fabay perot 現象，而跟寬頻譜光源量測系統做比較雖然有高靈敏度，但穩定性上卻來的較不穩定。相信只要解決穩定性的問題，雷射在生醫感測上絕對會是一大優勢。

Due to the progress of the optoelectronic industry in recent years and the people with diabetes are getting younger, many people have become interested in glucose detection again. Optical biomedical sensors have considerable potential in improving people's lives with diabetes by conveniently performing glucose detection every day. The surface plasmon resonance (SPR) interference system has gradually replaced the traditional method in biomedical detection. It is widely used in sensing various diseases because it has high sensitivity detection characteristics for objects to be tested with different refractive indexes.
SPR is executed through the resonance absorption of surface plasma wave by the
evanescent wave of transverse magnetic (TM) polarized mode. SPR usually has three
different structures to obtain surface plasma coupling, prism coupling, grating coupling,and waveguide coupling. In this paper, prism coupling and phase modulation are used for characterization. Due to its higher sensitivity, it is the most effective approach to use the phase for biosensing at a fixed angle or resonant wavelength.
The resolution of our 1310-nm tunable laser is 3-pm, better than 10-pm OSA resolution, and then utilized to improve the biomedical sensing sensitivity. Because the coherence length of the broad spectrum source is shorter, while the interference length of the swept laser with a narrow linewidth is longer, it is relatively easy for the laser to interfere with other resources and cause unstable interferograms, such as the Fabry-Perot effect. Once the stability problem is resolved, the laser will be a significant advantage in interferometer-based SPR biosensing.

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