本研究以熱塑性聚胺基甲酸酯(thermoplastic polyurethane TPU)作為基材，加入聚乙二醇(PEG)當作造孔劑，以二甲基甲醯胺(DMF)和四氫呋喃(THF)當作溶劑做成中空管。然後利用紫外光臭氧機活化內表面，進行表面接枝聚合反應，使內表面產生羧酸基(-COOH)，進而將明膠(gelatin)固定於TPU表面，藉以增進中空管的親水性、生物相容性與血液相容性。所得TPU管以SEM觀察其表面型態、以XPS分析元素組成、以及拉伸試驗與接觸角、L929纖維母細胞探討細胞相容性與貼附性，並以APTT與PT分析血液相容性，找出最適合的參數，以作為人工血管之應用。結果顯示過氧化物量密度在臭氧處理30分鐘達最高值，材料並無釋放毒性物，凝血時間無異常，而以明膠作為延伸鏈，可大幅提高細胞貼貼附數量。

In this study, thermoplastic polyurethane (TPU) tubes were prepared through phase inversion method using a cosolvent of N,N-dimethyl formamide (DMF) and tetrahydrofuran (THF). The resultant tubes were subsequently treated with UV-ozone to activate the surface. After grafting with acrylic acid (AA), gelatin was covalently immobilized onto the surface.
Scanning electron microscope (SEM) was use to examine the surface morphology of the tube. Further characterization included XPS, tensile strength, burst pressure, contact angle, and hemocompatibility such as activated partial thromboplastin time (APTT) and prothrombin time (PT). In addition, in vitro cytocompatibility was evaluated with L929 fibroblasts. The results show that the modification did improve the adhesion of fibroblasts without cytotoxicity and thrombogenicity.

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