本研究以碳酸二甲酯與乙醇進行酯類置換反應，產製生物可分解之綠色化學品碳酸二乙酯及另一有用的甲醇化學品為研究的重點。碳酸二乙酯是一種工業界重要的溶劑和中間體用來取代光氣以製備norfloxacin，norfloxacin是一個廣泛被使用的抗生素。碳酸二乙酯也能用來製備其他藥物，如苯巴比妥(一種鎮靜催眠劑)。碳酸二乙酯同時也是在肥料、農藥、及聚合工業中一種重要的反應物，並在鋰離子電池中廣泛的被用做電解液。本反應系統中有兩個可逆反應，會先產生中間體碳酸甲乙酯後才反應為碳酸二乙酯。以往的文獻只有討論到碳酸二乙酯的製造。如Mueller and Kenig(2007)和Luo and Xiao(2001)都只有描述了碳酸二乙酯能從反應蒸餾塔塔底得到，並未能探討整廠製程最佳設計，以及如何控制此製程。在本年度的計畫中，我們先使用Aspen plus進行穩態模擬，研究中將探討從反應到分離之完整程序，並以最小總年度成本(TAC)為目標，先得到反應蒸餾塔最適化之穩態設計及操作條件；再接著探討若後段分離製程採用簡單蒸餾方式的年度總預算，將反應蒸餾塔與簡單蒸餾塔之年度總預算相加，進而將其整合為整廠最適化之穩態設計。再來討論當最適化反應蒸餾塔加上前置反應器後之影響，最後則探討傳統反應器製程，並比較此三種系統的優劣。本研究中亦會探討整廠製程之控制策略，期能在各類干擾下仍能保持產物的純度。最後在產量增減之變化下，本研究提供了一個溫度控制器設定點的改變以期能完美的控制住產量增減時各產物流之純度。

A reactive-distillation system to produce diethyl carbonate (DEC) and methanol (MeOH) from dimethyl carbonate (DMC) and ethanol (EtOH) via consecutive two trans-esterification reactions is proposed in this study. Kinetic model parameters from Mueller and Kenig (2007) are used in this study. Suitable thermodynamic model parameters from regressions of experimental data are also established to describe the vapor-liquid equilibrium behavior of this system. Optimal process design and operating conditions are obtained by minimizing total annual cost (TAC). The distillate of the reactive-distillation column is a mixture of ethanol and methanol. In order to recover the excess EtOH to be recycled to the reactive-distillation column, this study using simple distillation to separate this mixture. Then compare between the optimal reactive-distillation and optimal reactive-distillation with a pre-reactor. After that, compare between conventional reactor with separation system and reactive-distillation system. Furthermore, a simple control strategy is proposed with only one tray temperature control loop in each column of the overall system. The proposed control strategy works effectively to hold the product compositions despite feed flow rate and feed composition changes. A set-point temperature adjustment scheme is proposed to maintain the purity of product composition when throughput change .

鄧耀斌，「乙酸乙酯反應器／蒸餾塔流程之設計與控制」，國立台灣科大學化學工程所碩士論文(2003) .

郭建麟，「丙烯酸乙酯製程之設計與控制」，國立台灣科大學化學工程所碩士論文(2005)

徐愷懌，「碳酸二甲酯反應蒸餾系統之設計與控制」，國立台灣科大學化學工程所碩士論文(2009)

羅安妮，「碳酸二乙酯反應蒸餾系統之設計」國立台灣科大學化學工程所碩士論文(2009)

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