本碩士論文主要以新穎材料金屬玻璃薄膜為研究方向，近年來金屬玻璃已被廣泛的研究，包含金屬玻璃製備的製程開發、機械性質與應用等。金屬玻璃有著獨特的特性諸如高強度、高硬度、抗腐蝕性佳以及好的抗磨耗特性，還有非常平滑的表面和絕佳的熱塑性性質，基於上述獨特性質，此金屬玻璃薄膜材料應用於醫療器材上極具潛力，像是抗菌鍍膜。故本研究是為利用磁控濺鍍鋯基(Zr53Cu33Al9Ta5)與銅基(Cu48Zr42Ti4Al6)金屬玻璃薄膜於矽基板和AISI 304不鏽鋼上，進而應用於醫療器械上，探討薄膜表面能、表面粗糙度、附著性等，更進一步進行抗菌性質之測試，評估其抑止細菌貼附表面及成長之機制。
相較於矽基板的水接觸角為48.8度，鋯基與銅基的水接觸角分別為119.5度及106.6度，可得知金屬玻璃薄膜之鍍覆可得到疏水性的表面改質。此一疏水表面特性於生醫材料上有極大的潛力作開發與應用。細菌及其他病原吸附於醫用材料表面是造成植入物感染的主因，其他在各類手術刀具之表面改質也相當可觀，一旦病原附著於材料表面，時間長了會生成一層薄的生物膜，文獻指出此生物膜必須使用比正常量多1000倍的抗生素甚至更多才能清除，故為避免此生物膜之形成，疏水之刀具或材料表面即相當重要!
此研究由變頻磁控濺鍍之金屬玻璃薄膜提供相當平滑的表面使病原無法附著於醫用材料表面，且腐蝕性佳，方便清洗及重複使用之特性，提供一病源無法附著的防禦力。由實驗結果可知，鋯基及銅基金屬玻璃薄膜皆具有顯著的抗菌效果。
金屬玻璃薄膜的抗菌機制也在此次研究的主要範疇，藉由微調日本工業標準(JIS Z 2801:2000)，調整不同的抗菌實驗方法，比較各種實驗方法得到的結果後，初鍍膜的金屬玻璃薄膜表面最平滑且具有最低的表面能及最大的疏水性質，可避免與細菌剛反應就附著上，但若多次接觸甚至浸泡在含有細菌的溶液中時，試片會緩慢釋出金屬銅及鋯離子，進而與帶負電的細菌反應，造成細菌死亡。

Thin films metallic glasses (TFMG) have demonstrated tremendous potential due to their high strength, high toughness, good corrosion, abrasion resistances, smooth surface and thermal plasticity. These materials are thus potentially useful for the medical application such as antibacterial coatings. In this work, Zr-based (Zr53Cu33Al9Ta5) and Cu-based (Cu48Zr42Ti4Al6) TFMGs was deposited on Si wafer and AISI 304 stainless steel via magnetron sputtering. We then evaluated the microstructure, surface roughness, amorphization and antibacterial properties of the thin films.
As compared to 48.8° on the bare Si wafer, the water contact angles of 119.5° and 106.6° for Zr- and Cu-based TFMGs, respectively, reveal the hydrophobic characteristic of the coated surfaces. The adhesion of bacteria to biomaterial surfaces is the main reason for implant-associated infection. Bacteria adhered to material surfaces for an extended period forms a biofilm. In this study, TFMG deposited has provided smooth surfaces to which bacteria would not easily attach so the mechanisms for resistance effects of TFMG to bacterial adherence are proposed. Furthermore, the bacterial adhesion of E. coli and S. aureus to both Zr-based and Cu-based TFMGs is hindered to different extents.

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