本研究以聚二甲基矽氧烷(Polydimethylsiloxane, PDMS)作為基材，與異佛爾酮二異氰酸酯(Isophorone diisocyanate, IPDI)及聚(乙二醇)甲基丙烯酸酯(PEGMA)進行聚合反應，合成PDMS-IPDI-PEGMA矽水膠共聚物(PIP macromer)。將不同比例之N-乙烯基-2-吡咯烷酮(N-Vinyl-2-pyrrolidone, NVP)加入至不同比例之 PIP macromer，並加入交聯劑乙二醇二甲基丙烯酸酯(EGDMA)和光起始劑2-羥基-2-甲基-1-苯基-1-丙酮(PI-1173)並以紫外光照射，形成新形態矽水膠共聚物PDMS-IPDI-PEGMA-NVP，並探討不同比例的矽水膠隱形眼鏡之可見光透光率測定(Transmittance)、傅立葉紅外線光譜分析(FTIR)、接觸角測定(Contact angle)、平衡含水量測定(EWC)、透氧係數測定(Dk)、拉伸試驗(Tensile test)、固態材料表面電位分析(zeta potential)、及生物相容性測試。研究結果表明，比例越高之 PIP macromer 隱形眼鏡透氧率顯著提升，含水量隨著 NVP 濃度的上升而增加。在任一比例下矽水膠隱形眼鏡的可見光透光率皆高於97%。拉伸試驗和接觸角測定會隨著NVP濃度的增加而有下降的趨勢。除此之外，細胞毒性測試結果顯示出良好的細胞成長率。因此，本論文所研究之隱形眼鏡材料具有良好的開發潛力。

In this study, polydimethylsiloxane (PDMS) was used as the base material, combined with isophorone diisocyanate (IPDI) and poly(ethylene glycol) methacrylate (PEGMA), was polymerized to synthesized PDMS-IPDI-PEGMA silicone hydrogel copolymer (PIP macromer). The resultant macromers were further reacted with N-vinyl-2-pyrrolidone (NVP) at varying ratios using ethylene glycol dimethacrylate (EGDMA) as the crosslinking agent and 2-hydroxy-2-methyl-1-phenyl-1-propanone (PI-1173) as the photoinitiator. After curing with ultraviolet light, the mechanical properties and biocompatibility of the resultant contact lenses were evaluated. The results revealed the oxygen permeability increased with the content of PIP macromer, while water content increased with increasing NVP content. All the contact lenses exhibited light transmittance above 97% for all compositions. Tensile testing and contact angle measurements showed a decreasing trend with increasing NVP concentration. Additionally, the cytotoxicity test demonstrated non-cytotoxicity. Thus, the contact lens materials in this study exhibit promising development potential.

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