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研究生： 阮妙翠
Nguyen - Thi Dieu Thuy
論文名稱： 咖啡酸、二氫咖啡酸雨二價金屬離子形成錯合物間之溶液平衡
Solution equilibria of complex formation between caffeic acid, dihydrocaffeic acid and divalent metal ions
指導教授： 朱義旭
Yi-Hsu Ju
口試委員: 王孟菊
Meng-Jiy Wang
Suryadi Ismadji
Suryadi Ismadji
Felycia Edi Soetaredjo
Felycia Edi Soetaredjo
學位類別： 碩士
Master
系所名稱： 工程學院 - 化學工程系
Department of Chemical Engineering
論文出版年： 2015
畢業學年度： 103
語文別： 英文
論文頁數： 95
中文關鍵詞： 咖啡酸 、二氫咖啡酸 、電位量測法 、分光光度法
外文關鍵詞： caffeic acid, dihydrocaffeic acid, potentiometry, spectrophotometry
相關次數： 點閱：192  下載：1 
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    • 本研究探討螯合劑(咖啡酸或二氫咖啡酸)與某些二價金屬離子(Cu2+, Zn2+, Ni2+, Co2+ 及Mn2+)在二成分或三成分系統中之溶液平衡。在37oC及 0.15 mol.dm-3 NaCl離子強度下利用電位量測以求得錯合物之質子化及形成常數。錯合模式及型態圖分別利用計算程式Hyperquad2008及HySS求得。此外，利用UV – Vis分光光度法驗證質子化常數之可靠度並定性確認錯合物之形成。
    在二成分及三成分系統中，金屬與螯合劑錯合物之穩定常數依下列順序遞減Cu2+ > Zn2+ > Ni2+ > Co2+ > Mn2+。金屬離子與二氫咖啡酸錯合物遠較金屬離子與咖啡酸錯合物穩定。此外，三成分系統中錯合物形成之趨勢可藉由計算相對穩定常數( )及非比例常數(log X)而得知。在生理酸鹼值下，咖啡酸及二氫咖啡酸之螯合遵循下列順序：pL0.5 (Cu2+) > pL0.5 (Zn2+) > pL0.5 (Ni2+) > pL0.5 (Co2+)> pL0.5 (Mn2+).

    The solution equilibria between chelating agents (caffeic acid – CA or dihydrocaffeic acid – DCA) and several divalent metal ions (Cu2+, Zn2+, Ni2+, Co2+ and Mn2+) in binary and ternary systems were investigated in this work. The potentiometric measurement was carried out at 37oC and ionic strength 0.15 mol.dm-3 NaCl in order to determine the protonation and formation constants of complexes. The complexation model and speciation diagram were established by computer programs Hyperquad2008 and HySS, respectively. Moreover, UV – Vis spectrophotometry was performed to explore the reliable protonation constants of these ligands and qualitatively confirm the complex formation.
    In both binary and ternary systems, the stability constant values of formed metal – chelator complexes decrease in the following order: Cu2+ > Zn2+ > Ni2+ > Co2+ > Mn2+. The complex formation between metal ion and DCA system is more stable than metal ion and CA system. In addition, the tendency of complex in the ternary system was revealed and evaluated by calculating the relative stability constant ( ) and the disproportionate constant (log X). Besides, at physiological pH, the sequestering ability of CA and DCA followed the order pL0.5 (Cu2+) > pL0.5 (Zn2+) > pL0.5 (Ni2+) > pL0.5 (Co2+)> pL0.5 (Mn2+).

    Recommendation Letter ii Qualification Letter iii 摘要 iv Abstract v Acknowledgement vi Table of Contents vii List of Tables x List of Figures xii Chapter 1. Introduction 1 1.1 Background 1 1.2 Objective 3 Chapter 2. Literature Review 4 2.1 Metal ions 4 2.1.1 Copper 5 2.1.2 Zinc 5 2.1.3 Nickel 6 2.1.4 Cobalt 7 2.1.5 Manganese 7 2.2 Chelating agents 8 2.2.1 Caffeic acid 9 2.2.2 Dihydrocaffeic acid 11 2.3 Complexation 11 2.3.1 The chelate effect 12 2.3.2 Classification of metal ions 13 2.3.3 The Irving–Williams series 14 2.3.4 CA and DCA in complex formation with metal ions 15 2.3.4.1 CA complexes 15 2.3.4.1 DCA complexes 17 Chapter 3. Experimental 18 3.1 Materials 18 3.2 Instrumentation 19 3.3 Experimental procedure 20 3.3.1 pH–potentiometric titration 20 3.3.2 UV–visible spectrophotometric measurement 21 3.4 Data analysis 22 3.4.1 pH–potentiometric data analysis 22 3.4.2 UV–visible spectrophotometric data analysis 23 Chapter 4. Results and Discussion 24 4.1 Protonation constants 24 4.2 Potentiometric studies of metal–ligand complexation 34 4.2.1 Complex formation in binary system 34 4.2.2 Complex formation in ternary system 47 4.3 Sequestering ability 56 4.4 UV–visible spectrophotometric studies of metal–ligand complexation 60 Chapter 5. Conclusion 65 References 68 Appendix 78

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