An intelligent transportation system (ITS) is regarded as a highly intelligent platform to provide innovative road services to the public. By introducing high-tech accurate predictions and reliable V2X (Vehicle-to-Everything) communications, ITS can provide safe, efficient, and low-carbon consumption travel experiences for road end users. The 3rd Generation Partnership Project (3GPP) has introduced a novel technology C-V2X (Cellular Vehicle-to-Everything). Through the use of C-V2X communications, the standalone sensor capabilities of a vehicle can be extended to the distances as far as the cellular network covers. As a good example of 5G’s advanced applications, autonomous driving with C-V2X deployment together will coincide and form a new ecosystem, and this ecosystem is changing how people will drive and how transportation will be managed in the future. In this dissertation, firstly, the latest global ITS development status was introduced. Secondly, C-V2X, autonomous driving, artificial intelligence, data security technologies, and how they collaborated in ITS were discussed. Thirdly, protocol designs, message flows, system architectures, experimental environments, and testing results in ITS applications were presented, and some exciting practical experiences in the implementation of C-V2X use cases in the open field were shared. Performance evaluation confirmed that C-V2X technology is promising. Finally, contributions, further development challenges and predictions on future research direction were summarized.

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