生物活性玻璃與其它生醫陶瓷材料相比，其浸泡在人體體液時能夠生成氫氧基磷灰石(Hydroxyapatite)，故具有骨頭修復能力，以58S比例之生物活性最佳。現今以溶膠-凝膠法為常用製備生物活性玻璃方法，其屬批次生產，故需要較長製備時間為其缺點。因此本實驗使用噴霧熱裂解法合成58S生物活性玻璃，能克服溶膠-凝膠缺點，使之達到量產化。

噴霧熱解法為一階段製程，但在製備生物活性玻璃過程中會受到熱處理影響晶體結構，並降低其生物活性。本研究透過控制三段不同熱處理溫度設定，能穩定製備非晶生物活性玻璃之最佳化熱處理溫度，並同時改變前驅液濃度，探討晶體結構。另外比較四乙氧基矽烷與四醋酸矽，做為不同矽之前驅物差異。前驅物溶液使用熱重分析儀判別其熱裂解溫度。粉體分析使用X光繞射儀以及聚焦型離子束顯微鏡，依序探討粉體晶體結構以及表面形貌。在體外生物活性測試將取製備後的粉體浸泡於模擬人體體液中，使用X光繞射儀及傅立葉轉換紅外線光譜儀分析其生物活性。最後依據不同熱處理溫度製備出非晶生物活性玻璃影響及生物活性進行探討。

最後，本實驗成功地利用熱處理溫度為575、100、25℃合成出58S非晶生物活性玻璃並量測其性質。

Bioactive glasses (BG) has outstanding bone regeneration than other bioactive ceramics, especially the 58S BG. When BG soaking in body fluid were form hydroxyapatite (HA) and which has good bioactive.
Sol-gel process is one of the most popular procedures for synthesis BG. However, drawbacks of long preparation time and discontinuous processing make that difficult to be mass produced. Using spray pyrolysis (SP) to synthesis BG can be fast synthesis time and mass production. Although SP is one step process, heat treatment will reduce bioactive due to crystal structures. Thus, in this study presented SP synthesis amorphous BG, which were under different heat treatments and use different silicon precursor.
The precursor solution has to characterized by thermogravimetric analysis to obtain its decomposition temperature. The crystallographic structure, morphology and chemical composition of BG specimens were characterized by X-ray diffraction, scanning electron microscopy and energy dispersive spectroscopy, respectively. In addition, in vitro bioactivity were characterized by FTIR and X-ray diffraction. Compare with powder crystal structure and bioactive by heat treatment. Finally, 58S BG has been successfully synthesis by using heat treatment with 575, 100, 25°C, respectively. Which has outstanding bioactive in vitro test.

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