具有奈米碳點(Cdot)在四氧化三鐵(Fe3O4)的表面與藻酸鹽(alginate)結合的奈米凝膠（Alg-Fe3O4@C）具有無毒性、高生物相容性、優異的光穩定性和良好的水分散性，適用於多種療法，如藥物傳輸，磁共振成像(MRI)以及溫熱療法。 通過奈米碳點塗覆在Fe3O4奈米顆粒，然後通過使用1-乙基-3-（3-二甲基氨基丙基）碳二亞胺（1-Ethyl-3-(3-dimethylaminopropyl)carbodimide）和N-羥基琥珀酰亞胺（N-Hydroxysuccinimide）作為酰胺化反應的偶聯劑將Fe3O4@C 與藻酸鹽作結合。 使用傅立葉變換紅外吸收光譜分析（FTIR），動態光散射儀（DLS，SZ-100），和透射電子顯微鏡（TEM）分析來研究Alg-Fe3O4 @ C的表面特徵。而在藥物乘載與藥物釋放方面，比起藻酸鹽，Alg-Fe3O4@C 具有較佳的表現。

Nanogels based on alginate combining carbon dots-coated magnetite (Alg-Fe3O4@C) with nontoxicity, high biocompatibility, excellent photo-stability, and good water dispersibility were synthesized for applications to multiple therapies like drug delivery, MRI contrast and hyperthermia. Fe3O4 nanoparticles were coated by carbon dots (Fe3O4@C), then combined with alginate by using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) and N-hydroxysuccinimide (NHS) as coupling agents of amidation reaction. The characterizations of (Alg-Fe3O4@C) were investigated using fourier transform infrared (FTIR) absorption spectroscopic analysis, dynamic light scattering instrument (DLS, SZ-100), zeta-potential and transmission electron microscopic (TEM) analysis. Loading and release of doxorubicin on the nanogels were larger than alginate nanogel.

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