Hench在1971年發現了生物活性玻璃(Bioactive glass)，接著由於BG的生物活性而吸引了許多學者爭相探討。BG會引起人體的生物反應，當植入人體時，會在值體、BG之間與主體組織產生強力的氫氧基磷灰石(Hydroxyl apatite, HA)化學鍵結，這項特色使BG適合作為牙醫的植入體、骨頭填充物等等的應用。因為HA生成的速率是改良形貌的重要參數之一，已有許多學者做過此研究，例如增加表面積，增加表面積的方法中，最常使用的方法之一為添加介面活性劑以在BG上產生介孔結構，即為介孔生物活性玻璃(Mesoporous bioactive glass, MBG)。前人研究顯示噴霧熱裂解法(Spray pyrolysis, SP)合成MBG可以改善溶膠凝膠法的缺點，然而，SP合成MBG的製程仍然需要下更多努力並加以改良。為了使SP合成MBG可以更完美，使用了不同種類、不同濃度的介面活性劑，本研究採用Pluronic F68、P123、F127作為介面活性劑，搭配14、31、44、53 wt%的濃度，並調查這些參數對MBG的影響且探討何種介面活性劑與何種濃度可以得到最佳的生物活性。分析不同種類、濃度的介面活性劑合成之MBG的晶體結構、形貌、表面積、化學組成，並探討不同種類的介面活性劑與濃度增加對MBG的影響，也藉由浸泡在人體模擬體液(Simulated body fluid, SBF)測量其生物活性，並分析、比較各個種類與濃度的介面活性劑的影響，比較是為了決定給予MBG最佳生物活性的介面活性劑之種類與濃度。

The discovery of bioactive glass by Hench in 1971 has attracted many researchers due to it bioactive property. Bioactive glass elicits biological response from the body that generate mechanically strong biochemical bond, hydroxyl apatite (HA), between implant, bioactive glass, with the host tissue when implanted in human body. This feature of bioactive glass makes it suitable for dental implant, bone filling and many other applications. Since the rate of HA formation is one of its important parameters modifications on morphology have been conducted by many researchers such as increasing the surface area. One of popular approach to increase the surface area is using surfactant as template to generate mesoporous structure in bioactive glass (mesoporous bioactive glass). Spray pyrolysis method has been used to synthesize MBG on previous studies as response to the disadvantage of using sol-gel method to synthesize MBG. However, synthesizing using spray pyrolysis still required many efforts to optimize the MBG produced. To optimize the MBG produced by the spray pyrolysis, various types and concentrations of surfactant are used. Surfactant Pluronic F68, P123 and F127 using various concentrations (14, 31, 44, 53 wt%) are used to investigate its effect on MBG and to study which surfactant and concentration of surfactant has the best bioactive property. MBGs synthesized by using different types and concentrations of surfactant are characterized its crystal structure, morphology, surface area and chemical composition and then studied the effect on it with the increasing concentration and using different type of surfactant. MBGs using different types and concentrations of surfactant also undergo bioactivity test by immersion in SBF (Simulated Body Fluid) and characterized to study the influence of each types and concentrations of surfactant and then compared. The comparison is to determine the most suitable types and concentration of surfactant that gives MBG with the best bioactivity.

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