生物活性玻璃 (Bioactive glasses) 藉由其優異的生物活性以及 可應用於多方面之潛力 (如藥物載體、骨植入物以及補牙骨粉等)，於近年來已取得許多生物學者及工程師之關注。溶膠-凝膠法為目前製備生物活性玻璃最普遍之方法，並於近20年來廣泛地用於製備生物活性玻璃，然而此方法因其為非連續性之製程，需要較長之製備時間為其缺點。因此，本研究將利用噴霧熱解法 (Spray pyrolysis) 一階段製備出生物活性玻璃來克服上述之缺點，並針對微結構與生物活性之關聯來做探討。實驗中成功地利用噴霧熱解法藉由含有Si、Ca、P元素之前驅物溶液製備出球形生物活性玻璃 (Spherical bioactive glass, SBG) 以及球形介孔生物活性玻璃 (Mesoporous bioactive glass, MBG)。前驅物溶液須利用熱重分析儀判別其熱裂解溫度，製備出的粉體將利用 傅立葉轉換紅外線光譜儀、X光繞射儀、掃描式電子顯微鏡、穿透式電子顯微鏡、氮氣吸/脫附分析儀來鑑定。最後，體外生物活性測試將取製備後的粉體浸泡於模擬人體體液中，並再次地利用X光繞射儀 分析其生物活性。而後證明添加界面活性劑能夠阻止相分離之發生並提升其生物活性。

Bioactive glasses (BGs) have attracted lots of attention recently from biologists and engineers due to their superior bioactive properties and possible applications such as drug carriers, bone implants and tooth repairing materials. The sol-gel method is one of the most popular procedures for fabricating BGs, and has been used to produce BGs for more than 20 years. However, there are some disadvantages like discontinuous processing and long processing time for the sol-gel method. In this study, spray pyrolysis (SP) method was presented to overcome these disadvantages by synthesizing BGs with one-step synthesis.The SP method has successfully synthesized spherical bioactive glass (SBG) and spherical mesoporous bioactive glass (MBG) particles by using Si-, Ca- and P-based precursors. The precursor solution has to characterized by thermogravimetric analysis to obtain its decomposition temperature, the resulting particles will be characterized by fourier transform infrared spectroscopy, X-ray diffractometer, scanning electron microscopy, transmission electron microscopy and nitrogen adsorption/desorption isotherm. Also, the in vitro bioactivity can be assessed by immersing the particles into simulated body fluid (SBF), and by characterization of X-ray diffractometer. At last, by adding surfactant in precursor solution, phase stability, mesoporous structure and higher surface area can be achieved.

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