本研究聚焦於改善二型糖尿病（Type 2 Diabetes）患者的胰島素阻抗問題，探索新型治療醫材的開發。二型糖尿病是一種常見的代謝性疾病，其主要特徵為胰島素阻抗及胰島素分泌不足，常伴隨多種嚴重併發症。現有治療方法包括生活方式干預、藥物治療、手術治療和內視鏡治療，儘管這些方法在一定程度上能夠控制病情，但仍存在諸多挑戰，如治療效果有限、副作用大以及患者依從性差等問題。
本研究提出並驗證了一種新型的組合腸道支架，其設計靈感來自於胃繞道手術，旨在減少食物與十二指腸壁的接觸，從而改善胰島素阻抗問題。支架結構分為固定段、連接段以及覆膜支架三部分，其中覆膜支架採用熱塑性聚氨酯（TPU）材料，透過旋轉軸式3D列印機進行製作，再藉由浸塗技術將支架進行覆膜。結果顯示，組合腸道支架於腸道模型中證實了能夠有效阻隔食糜與腸壁的接觸，以此改善胰島素阻抗，並且固定段及連接段設計能夠有效防止腸道支架產生滑移及避免膽道口封閉等問題。
此外，本研究提出一新型十二指腸黏膜表面重塑（Duodenal Mucosal Resurfacing，DMR）手術方法及裝置。本研究創新地使用超音波技術，透過可傳導超音波的加熱板與腸壁接觸，以進行十二指腸黏膜的加熱消融，從而促進上皮細胞再生，改善胰島素敏感性。實驗顯示，超音波DMR手術裝置原型可於三秒內加熱腸道表層至60C，此結果顯示創新裝置的高消融效率及有效降低較深層組織損傷的可能性，具有潛在的臨床應用價值。總結來說，本研究所提出的組合腸道支架與超音波DMR手術為二型糖尿病的治療方式提供了新的解決方案，並為未來相關研究提供了重要參考。

This study focuses on improving insulin resistance in patients with Type 2 Diabetes (T2D) through the development of innovative therapeutic medical devices. T2D is a common metabolic disorder characterized by insulin resistance and insufficient insulin secretion, sometimes accompanied by severe complications. Current treatment methods include lifestyle interventions, pharmacotherapy, surgical treatment, and endoscopic treatment. While these methods can control the disease to some extent, they still present many challenges, such as limited therapeutic efficacy, significant side effects, and poor patient compliance.
This study proposes and validates a novel combined intestinal stent, inspired by gastric bypass surgery, designed to reduce the contact between food and the duodenal wall, thereby improving insulin resistance. The stent structure consists of three parts: the fixed segment, the connecting segment, and the covered stent. The covered stent is made of thermoplastic polyurethane (TPU) material, manufactured using a specialized 3D printer with a rotational axis, and coated using by dipping technology. Results show that the combined intestinal stent effectively prevents the contact between chyme and the intestinal wall in an intestinal model, thus improving insulin resistance. Additionally, the design of the fixed and connecting segments effectively prevents stent migration and avoids the closure of the biliary duct.
Furthermore, this study proposes a novel method and device for duodenal mucosal resurfacing (DMR). Innovatively using ultrasound technology, the device employs an ultrasound-conductive heating plate to contact the intestinal wall for duodenal mucosal heating ablation, promoting epithelial cell regeneration and improving insulin sensitivity. Experiments show that the prototype of the ultrasound DMR device could heat the intestinal surface to 60°C within three seconds, demonstrating high ablation efficiency and significantly reducing the possibility of deeper tissue damage, showing potential clinical application value. In summary, the combined intestinal stent and ultrasound DMR surgery proposed in this study offer new solutions for the treatment of T2D and provide important references for future related research.

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