目前使用生醫材料來製作神經管的材料大部分是使用矽膠管，雖然矽膠製神經管具有高生物適應性及高柔軟度的優點，但不易被生物體降解。且過去研究中發現微溝槽表面可以最有效地引導許旺氏細胞和神經元的生長，但因為製程上的困難無法製作精度較高的導管。因此本研究將使用DLP製程來製作具有微溝槽結構可降解之神經導管。
使用DLP製程可以有效簡化過去製作一個神經管所需的多個生產技術，可製作尺寸微小的微溝槽結構。材料方面挑選PGSA及PEG-DA作為可降解神經導管主材料，對其進行降解試驗與拉伸試驗。結果顯示PGSA與PEG-DA混和材料具有降解性的同時具有一定的機械強度。另外發現當材料PGSA60+PEGDA=1:1另外添加15%PEG後的降解百分率可提升為原先的3倍。此外，細胞培養觀察到細胞在PGSA30+PEGDA=1:2 PATTERN支架上生長狀況佳、能均勻分布，且細胞沿著微溝槽的方向排列、生長。最後，老鼠動物實驗證明神經導管具有生物相容性，且具備足夠機械強度能真正實際運用在生物體上，使受傷之神經管進行再生與修復。

At present, most of the materials used to make nerve conduit using biomedical materials are silicone conduits. Although silicon nerve conduit are high biocompatibility and high softness, but they are not easily degraded. And in the past research, it was found that the surface of microgrooves can most effectively guide the growth of Schwann cells. Therefore, this study will use the DLP process to fabricate degradable nerve conduit with microgroove structures.
Using the DLP process produce micro-groove structures with small dimensions. PGSA and PEG-DA were selected as the main materials of the degradable nerve conduit, and degradation tests and tensile tests were performed on them. The results show that the PGSA and PEG-DA mixed materials are degradable and have certain mechanical strength. It was also found that when the material PGSA60 + PEGDA = 1: 1 and the addition of 15% PEG, the degradation percentage could be increased by three times. In addition, in cell culture, it was observed that the cells grew well on the PGSA30 + PEGDA = 1: 2 PATTERN scaffold and could be evenly distributed, and the cells were arranged and grown along the direction of the micro grooves. In the end, rat animal experiments proved that the nerve conduit are biocompatible and have sufficient mechanical strength to be used in living organisms to regenerate and repair injured nerve conduit.

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