皮膚是對抗病原入侵的第一道防線。傷口癒合在臨床上的威脅以糖尿病最為嚴重。本實驗將選擇紫雲膏、雷公根、Heparinoid之三款傷口癒合藥物，來觀察對於正常人的體表微循環供血之效應。
本研究我們對受測者進行心電訊號、動脈血壓波形、血管光容積訊號和雷射都普勒血流等非侵入式量測。受測者為正常人右側定義為對照組；左側定義為實驗組。第一筆量測數據作為空白數據(M0)與第二筆量測數據稱作為對照組(M1)相比來進行探討。並觀察使用的血流參數能否有效評估此一改善效應。
我們採用的許多參數分析指標具有顯著的解析能力，且在3藥物組中觀察到不同的血流效應。希望在未來能透過血流的參數改變，評估傷口復原狀態監控，並將受測數據搭配雲端傳輸，進行即時評估與解析。

Wound healing an important topic in clinical application. The present study aimed to compare the different microcirculatory effects between the following three drugs: Comfrey balm, Centella, and Heparinoid.
We measured electrocardiogram (ECG), blood pressure waveform (BPW), photoplethysmography (PPG), and laser Doppler flowmetry (LDF) signals on the skin surface of healthy subjects. The left side is defined as the experimental group; the right side serves as the control comparison.
There are several significant changes in the present indexes following applying the drugs, with different response among the three groups.
In the present study, we confirmed the feasibility of this research, In the future, we hope to monitor the wound healing status monitoring through analyzing the microcirculatory-blood-flow indexes.

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