傷口敷料是傷口照護中重要的一環，傷口敷料的最大特點是能使傷口保持濕潤環境、減少
疤痕的形成、舒緩患者的疼痛以及避免傷者的體液流失過快。然而當傷口敷料敷在傷口一段時
間之後，吸收組織液之後會與皮膚產生沾黏，在移除的同時可能會造成傷口的二次傷害以及患
者的不適。本研究欲開發具有可逆性質的水膠作為傷口敷料，利用其可逆性質使得水膠可以從
傷口上移除。Pluronic F-127 是一種感溫可逆的水膠材料，它的成膠原理與其濃度與溫度息息相
關，隨著溫度增長它會交聯形成凝膠，而到低溫時則會回復為溶液，除此之外，藻酸鹽(Alginate
acid)也是一種離子成膠的凝膠材料，其本身帶負電因此可以包覆帶正電的材料如小分子蛋白。
預期以 Pluronic F-127 與藻酸鹽作為傷口敷料，可以利用雙重特性製作出感溫離子可逆型傷口
敷料。因此凝膠擁有兩種不同成膠性質的材料在相互作用，實驗中使用 DLS、流變儀以及 sol-gel
transition 來觀察兩種成膠方式是否會相互影響成膠性質、機械強度以及可逆性。另外，利用掃
描 Pluronic 及 Alginate 拉曼訊號我們可以對此複合凝膠做 3D 成像，結果顯示此兩種材料呈現
層狀結構堆疊，同時掃描式電子顯微鏡分析顯示此複合型凝膠會在表面形成孔洞。此凝膠除具
備感溫離子可逆特性外同時也具備生物可相容性，進一步傷口復原的實驗中，包覆血管內表皮
生長因子(VEGF)之可逆凝膠有助於加速傷口復原及減少二次傷口產生。

Wound dressings are an important part of wound care. The most prominent feature of
wound dressings is to keep the wounds moist, reduce the formation of scars, relieve the pain of the patients and avoid excessive fluid loss in the wounded. Hydrogel is currently a very common material for wound dressings, which are themselves very hygienic gels which, as a wound dressing, possess the above mentioned characteristics and, because of their inherently transparent nature, make it easier to observe wound healing Case. However, when the wound dressing is applied to the wound for a period of time, it may stick to the skin after absorbing the tissue fluid, which may cause secondary wound damage and discomfort to the patient while being removed. In this study, we attempted to study the reversible hydrogel as a wound dressing and use its reversible properties to remove the hydrogel from the wound. Pluronic F-127 is a thermoreversible hydrogel aterial whose principle of gelation is related to its concentration and temperature. As the temperature increases, it crosslinks to form a gel and returns to solution at low temperatures Alginate is also an ionic crosslinked hydrogel material that itself has a negative charge and therefore can coat positively charged materials such as small proteins. In this study, Pluronic F-127 blended with alginate are expected to be used as smart wound dressings, making it possible to use their properties to create thermal and ionic reversible wound dressings.

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