本研究將四乙氧基矽烷(TEOS)或3-胺基丙基三乙氧基矽烷(APTES)當作前驅物，利用溶膠–凝膠法(sol-gel)前段溶膠態製程，並利用鹽酸當作催化劑，藉由水解及縮合反應合成出二氧化矽奈米粒子溶膠液及末端為胺基(-NH2)矽粒子溶膠液，接著將兩種溶膠液分別依不同比例混摻於甲基丙烯酸-2-羥基乙酯(HEMA)溶液，並且加入親水性N-乙烯基吡咯烷酮(NVP)、交聯劑乙二醇二甲基丙烯酸酯(EGDMA)及丙三醇(glycerol)均勻混合後，接著利用紫外光交聯反應形成不同混摻比例之HEMA水膠薄膜，並探討不同混摻比例HEMA水膠薄膜之透光率、平衡含水率、透氧係數、接觸角、拉伸強度、蛋白質吸附及細胞毒性等基本性質。

In this study, either tetraethyl orthosilicate (TEOS) or 3-aminopropyl triethoxysilane (APTES) was used as the precursor, hydrochloric acid (HCl) was used as catalyst to cause hydrolysis and condensation reaction to produce emulsions of silicon dioxide (SiO2) nanoparticles (NP) and SiO2 NP with amino groups (-NH2), respectively. Either emulsion was mixed in different ratios with 2-hydroxyethyl methacrylate (HEMA). Afterward N-vinyl-2-pyrrolidone (NVP), ethylene glycol dimethacrylate (EGDMA) as crosslinking agent, and glycerol were added into the system. The polymerization was initiated with ultraviolet to gel the solution. The effect of the content of SiO2 or SiO2-NH2 on the equilibrium water content (EWC) and optical transmittance, oxygen permeability, contact angle, tensile strength, protein adsorption and cytotoxicity was investigated.

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