一般傷口癒合過程中常常會受到過量氧自由基和細菌感染的阻礙，傷口為產生豐富的活性氧化物(Reactive Oxygen Species; ROS)來抵抗病原菌，反而使細胞內反應性氧化物的累積導致氧化壓力，進而損害細胞組成成分並啟動細胞死亡機制。因此理想的傷口敷料應具有良好的ROS清除性能和相當的抗菌能力。在本論文中，利用源自於植物-單寧酸(Tannic Acid; TA)的抗氧化能力，以TA為主體與醋酸纖維素(Cellulose Acetate; CA)載體進行電紡來製備奈米複合膜，並引入ZrIV離子與TA自組裝合成金屬多酚網(Metal-Phenolic Networks; MPNs)，透過萬能試驗機測試奈米複合膜的拉伸強度，證實了當ZrIV離子與TA產生交聯之後的楊氏模量提升1.5倍，且同時間下與無添加ZrIV離子相比，減少了50% 的TA於水中的釋放速率。此外利用TA的還原性能將銀氨溶液(托倫試劑)在奈米纖維表面上原位還原出銀奈米顆粒(AgNPs)，以簡單方式構建了一種具有優異抗氧化活性和出色抗菌性能的新型奈米複合膜敷料。接著以950 μL之DPPH･(0.15 mM)作為模擬之自由基與50 μL溶有奈米複合膜之溶液 (0.2 mg mL-1)反應，可於可見光光譜中517 nm處之特徵峰觀察到吸光值從1.52下降到0.55，由公式得出對自由基之去除率達到67%，證實所製備的奈米複合膜具有抗氧化去除自由基的能力。XRD分析鑑定奈米纖維表面上之奈米銀平均直徑為9.2 nm。此外，TGA證實了奈米銀佔奈米複合膜總重量大於50%，也說明此TA奈米複合膜具高度還原能力。此奈米複合膜尤其對大腸桿菌具有非常突出的抗菌效果，與OD 值為1之菌液接觸1 小時之內能達到100%之消滅率。再以L929細胞進行測試，透過MTT方法證明了所有的奈米複合膜皆能促進細胞增殖，具有良好的生物相容性。

During the wound healing process, the presence of excessive reactive oxygen species (ROS) and bacterial infections often impede optimal wound recovery. Wound generally generates abundant ROS to counteract pathogens; however, this paradoxically leads to oxidative stress within cells due to the accumulation of ROS. Therefore, an ideal wound dressing materials should possess robust ROS scavenging capabilities along with an effective antibacterial activity. In this study, the antioxidant capacity of tannic acid (TA) was harnessed to fabricate a nanocomposite membrane along with cellulose acetate (CA) via electrospinning. Zirconium IV (Zr IV) ions were employed to form metal-phenolic networks (MPNs) with TA in the electrospun TA-CA nanofibers consisted nanocomposite. Tensile strength of the nanocomposite membrane revealed a 1.5-fold increase in Young's modulus upon crosslinking with Zr ions. Concurrently, the release rate of TA from nanocomposite decreased 50% as compared to the case in the absence of Zr ions for crosslinking. Furthermore, silver nanoparticles (AgNPs) were synthesized in situ on fiber surface via the reduction of silver ammonia solution (Tollen's reagent) due to the reductive activity of TA. This facile and novel nanocomposite membrane prepared demonstrated its exceptional antioxidant and antibacterial activities. X-ray diffraction analysis confirmed an average diameter of 9.2 nm for the silver nanoparticles deposited on the fiber surface. Thermogravimetric analysis (TGA) showed that AgNPs constituted over 50% of the total nanocomposite weight. Within 1 hour contact with Escherichia coli suspension of OD 1.0, 100% eradication was observed. Cell viability assays using L929 cells via MTT method underscored the positive impact of all nanocomposite membranes on cell proliferation, attesting to their favorable biocompatibility.

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