氧化石墨烯因為其非凡的電學，熱學，機械和結構特性而受到極大的關注在材料科學領域。近年來也一直致力於探索石墨烯氧化物在生物醫學應用潛力。而碳塗覆的鐵納米顆粒是一種新型的磁性納米粒子的可在腫瘤部位通過一個局部地施加的外部磁場被保留。在這項研究中，關於環糊精結合石墨烯氧化物的合成和表徵，與碳塗覆鐵的奈米顆粒的分析和碳塗覆鐵的奈米顆粒結合石墨烯氧化物已經成功完成。此外，將氧化石墨烯，氧化石墨烯結合環糊精和碳塗覆鐵的奈米顆粒結合石墨烯氧化物來當作癌細胞識別結合的官能基，以及搭載抗癌藥物阿黴素。結果表明阿黴素在氧化石墨烯結合環糊精上的裝載量總是比氧化石墨烯高，因為在環糊精可包含阿黴素。而碳塗覆鐵的奈米顆粒結合石墨烯氧化物有很高的藥物載體，因為碳塗覆鐵的奈米顆粒可以通過π-π堆積，疏水性和氫鍵提高裝載量。
藥物釋放曲線示表示出很強的酸鹼度依賴性，尤其是當藥物和納米材料的相互作用力是基於氫鍵。藥物釋放行為應用在酸鹼度值5和酸鹼度值7。由於微環境中的腫瘤和細胞內溶酶體和內涵體的細胞外組織是酸性的。

Graphene Oxide has received tremendous attention in the field of materials science because of its extraordinary electrical, thermal, mechanical, and structural properties. Recently, great efforts have also been devoted to explore potential application of graphene oxide in biomedicine. Carbon coated iron nanoparticles are new kind of magnetic nanoparticles can be retained at tumor sites by a locally applied external magnetic field. In this study, the synthesis and characterization of cyclodextrin-immobilized graphene oxide (GO-CD), carbon coated iron nanoparticles (Fe@C) and Fe@C-bound GO-CD were successfully performed. Furthermore, the controlled loading of doxorubicin (DOX), an anti-cancer drug, onto GO, GO-CD, Fe@C, Fe@C-bound GO and Fe@C-bound GO-CD was investigated. It showed that the loading capacity of DOX on GO-CD was always higher than GO, since the inclusion of DOX in CD. Fe@C-bound GO-CD was most high because loading of DOX on Fe@C can occur via π-π stacking, hydrophobic and hydrogen bonding.

The release profile shows strong pH dependence, especially when the interaction forces of the drug and nanomaterials are based on hydrogen bonds. And drug release behavior was invested at pH 5 and pH 7 due to the micro environments in the extracellular tissues of tumors and intracellular lysosomes and endosomes are acidic.

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