本文以甲基丙烯酸-2-羥基乙酯(2-Hydroxylethyl methacrylate, HEMA)及親水性抗蛋白單體甲基丙烯酸聚乙二醇酯(poly(ethylene glycol) methacrylate, PEGMA)為單體，再加入diethoxy acetophenone (DEAP) 光起始劑以及交聯劑Tetraethyl Orthosilicate (TEOS)，以UV起始法經由自由基共聚合製備HEMA-PEGMA水膠，以提高HEMA水膠之親水性以及增加其抗蛋白性。
根據實驗結果得知，HEMA-PEGMA水膠的含水率隨著PEGMA的含量增加而上升，而接觸角也因PEGMA的加入而降低，因而提高水膠的親水性。此外，氧穿透率(oxygen transmittance，Dk )也相對增加。相反地，其機械強力(mechanical strength)方面卻會隨著PEGMA的增加而有下降的趨勢。HEMA-PEGMA水膠的透光度在可見光範圍可達94%以上。而在蛋白質吸附試驗中，我們利用BCA 蛋白質測定方法來探討，結果顯示隨著PEGMA的含量增加，能夠明顯的降低蛋白質吸附。在細胞毒性方面，以ISO10993-5的判定上屬於0-1 級，所以其細胞毒性是通過標準的。針對這些特性，未來可以利用此水膠來作為隱形眼鏡及眼科材料之運用。

In this work, hydroxyethyl methacrylate (HEMA) was copolymerized with poly(ethylene glycol) methacrylate (PEGMA) into hydrogel via ultraviolet (UV) initiation with diethoxy acetophenone (DEAP) as the initiator and tetraethyl orthosilicate (TEOS) as the crossliking agent to increase hydrophilicity and anti-protein adsorption.
The results show that the increase in PEGMA content led to the decrease of water contact angle and the increase of water content (EWC) for the blend hydrogels. Moreover, the oxygen transmittance (Dk) increased with the increase of EWC. The mechanical strength of the hydrogel also decreased with the PEGMA content. The HEMA-PEGMA hydrogels exhibited high optical transmittance (over94%). When the PEGMA content reached 20%, the apparent protein adsorption amount decreased to about 75% of that of HEMA control. Thus the HEMA-PEGMA hydrogels exhibited the ability to resist protein adsorption. Furthermore, these hydrogel were non-cytotoxic through in vitro L929 fibroblasts proliferation assay. Overall results demonstrated that the HEMA-PEGMA hydrogels exhibited relatively high oxygen permeability, hydrophilicity, optical transparency, and anit-protein adsorbtion , therefore would be applicable as contact lens material.

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