據研究顯示，生物活性玻璃比其他陶瓷材料可刺激更多的骨再生，並對於刺激骨母細胞的分化具有正向的影響。當生物活性玻璃植入體內後，可於表面沉積氫氧基磷灰石，並與原生骨骼產生鍵結，以加快修復受損骨骼與組織生長。此外，生物活性玻璃亦可透過摻雜功能性元素達到不同地治療效果，其中硼元素不僅可增加生物活性、機械性質及降解能力，還可以促進傷口癒合、釋放生長因子及細胞因子、增加 RNA 的合成，除此之外還能增加血管內皮生長因子(VEGF)、白血球介素6(IL-6)以及鹼性成纖維細胞生長因子(bFGF)的分泌、刺激血管的生成以加快傷口修復的速度。故本研究擬以硼元素作為摻雜之功能性元素，並添加不同的酸催化劑並觀察其影響。實驗結果顯示所有樣品均具有生物活性，且在摻雜濃度較高樣品中具有加快氫氧基磷灰石生成的能力。於生物相容性方面，各樣品於150mg/ml濃度下之萃取液均通過ISO10993-5規範並無細胞毒性，且細胞存活率與摻硼濃度成正比關係。

Bioactive glass could stimulate more bone regeneration than other ceramic materials and has a positive effect on stimulating the differentiation of osteoblasts. After implanted into the human body, layers of hydroxyapatite could be formed on the surface and bond with the native bone to accelerate the repair of damaged bone and tissue growth. Additionally, the material itself can achieve different therapeutic effects through the doping of functional elements. Among the functional elements, Boron could not only increase bioactivity, mechanical properties, and degradation ability but also promote wound healing, release growth factors and cytokines, increase RNA synthesis and secretion of vascular endothelial growth factor (VEGF), interleukin-6 (IL-6), and basic fibroblast growth factor (bFGF), thus stimulating vascular formation to help wound healing. Therefore, this study proposes using boron as the functional element for doping. Experimental results show that all specimens are bioactive and have the ability to accelerate hydroxyapatite generation in high doping concentrations. In terms of biocompatibility, all specimens passed ISO10993-5 regulations and showed no cytotoxicity in the extraction solution at 150mg/ml, with cell survival rates increasing proportionally with boron doping concentration.

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