研究生: |
林偉翔 Wei-shiang Lin |
---|---|
論文名稱: |
製備與功能化Zn-CuInS2水溶性量子點於生物顯影及抗癌藥物載體 Preparation and Surface Functionalization of Zn-CuInS2 Quantum Dots for Bioimaging and Anticancer Drug Delivery Applications |
指導教授: |
張家耀
Jia-yaw Chang |
口試委員: |
王勝盟
Sheng-meng Wang 何郡軒 Jinn-hsuan Ho |
學位類別: |
碩士 Master |
系所名稱: |
工程學院 - 化學工程系 Department of Chemical Engineering |
論文出版年: | 2014 |
畢業學年度: | 102 |
語文別: | 中文 |
論文頁數: | 107 |
中文關鍵詞: | I-III-VI族量子點 、水相量子點 、藥物釋放 、藥物載體 、胺基苯硼酸 、細胞顯影 |
外文關鍵詞: | quantum dot, doxorubicin, drug delivering, drug release, phenylboronic acid, cell Imaging |
相關次數: | 點閱:236 下載:0 |
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本論文結合了奈米合成技術與生物醫學應用,將低毒性之量子點應用於細胞體上,作為顯影標靶與藥物載體之功能。第一部分的實驗主要是以水為溶劑來合成Zn-CuInS2 (ZCIS)量子點,並藉由優化Cu、In與Zn等前驅物比例,提高量子點之量子產率,以及使用雙穩定劑穀胱甘肽與聚丙烯酸鈉來使量子點能夠在水中穩定地合成出來;接著將核層量子點以無機材料ZnS包覆而形成核殼型量子點ZCIS/ZnS,可明顯提高量子點的螢光量子產率至16.8%,並利用穿透式電子顯微鏡、X光繞射儀與螢光光譜儀來進行量子點組成、結構、光學性質之分析。第二部分則是將量子點功能化,使用胺基苯硼酸修飾於量子點表面,提高量子點之生物相容性,並以共軛焦距顯微鏡偵測材料於Hela細胞體內之顯影效果。最後則是將功能化之量子點作為奈米藥物載體,利用抗癌藥物DOX與量子點中Zn2+離子之配位關係,將DOX裝載於量子點上,並於癌細胞之酸性環境中釋放出DOX,以達到抑制癌細胞之效果。
In this research, we investigate the synthesis process of quantum dots and its biomedical applications on cell imaging along with delivering anticancer drug. In the beginning, we directly synthesize water-soluble Zn-CuInS2 quantum dots (ZCIS QDs) facilitated by polyacrylic acid and L-glutathione as stabilizing and reactivity-controlling agents. The optimization of copper, indium and zinc ratio to improve the quantum yields of ZCIS QDs also become important part to be improved on this research. Moreover, by ZnS coating on the surface of ZCIS QDs, the quantum yield value can be increased significantly to 16.8%. We further conjugate 3-aminophenylboronicacid as cancer targeting agents onto ZCIS/ZnS QDs via formation the cyclic boronate ester with sialic acid on the membrane of cell. Beside evaluate its imaging potential with confocal microscopy, the competence of ZCIS/ZnS QDs as platform for targeted and pH responsive intracellular delivery of an anticancer drug also improved. Therefore, Doxorubicin is loaded onto the APBA functionalized ZCIS/ZnS QDs by formation of metal complexes with Zn2+ on the QDs. The conjugation of DOX on ZCIS/ZnS@APBA QDs can be maintained at physiological condition, but directly break in the mildly acidic condition like on intracellular environment of cancer cells. Hence, this approach can provide nanovector-based material as simultaneous targeting and therapy of cancer cells.
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