生醫光電是一成長迅速的研究領域，而且已成為生物科技重點發展項目之一。近年來，研究人員提出將微環形諧振器(Microring Resonator; MRR)用於無標記生物感測應用，由環內強電場增強引起的高品質因子(Q)使得MRR成為有效地分析檢測生物分子之微小濃度引起折射率變化檢測的良好候選者。本論文我們提出用空間相位量測法來展示干涉之MRR的最高的靈敏度，此靈敏度可推導成微環形諧振器的有效長度。由於微環形諧振器有效長度與品質因子Q成正比，所以eye-like 微環形諧振器與基於Sagnac原理的Fabry-Perot析光器將被使用以增進提升品質因子Q。此新穎式生物感測器之解析度理論上可以達到至少1.3×10-6 RIU。我們運用光纖通訊波段之寬頻譜作為低同調干涉光源，並採用兩級馬赫詹德(Mach-Zehnder)干涉儀作為此實驗架構主體，其優勢在於生醫感測上空間相位解析能力好，並具有干涉基準點與光學尺的優勢。
本論文中，以兩級Mach-Zehnder干涉儀以及低同調光源作為實驗架構主體，並結合微環形諧振器的共振現象達到醫學感測的目的，也因為使用兩級的Mach-Zehnder干涉儀，成功解決一級的Mach-Zehnder干涉儀沒有基準點可以作為濃度變化依據的問題，並在數據處理上以MATLAB將干涉波包以高斯曲線擬合(Gaussian Curve Fitting)之方式分析不同濃度待測物的變化，其靈敏度為49 μm⁄μM，且解析度可達到1.53 nM。

Biophotonics is a rapidly growing field in prevailing researches and becomes one of the major developed projects of biomedical technology. In recent years, the microring resonator (MRR) has been utilized for label-free biosensing applications. The high quality factor (Q) from the strong electric field enhancement within the ring makes the MRR a good candidate for biomolecule detection under low analyte concentration conditions. Here we propose the MRR interrogated with an interferometry to demonstrate the highest spatial phase sensitivity, which can be derived to a MRR effective length. Since the MRR effective length is proportional to the quality factor Q, the eye-like MRR and sagnac based Fabry-Perot etalon will be implemented to enhance Q factor. Finally, the biosensing resolution can theoretically achieve at least 1.3x10-6 RIU. A broad band source with the fiber communication wavelength range will be utilized for the Mach-Zehnder based optical low coherence interferometry (OLCI) system. Moreover, a two-staged OLCI is intentionally built to demonstrate better spatial phase resolution, interferogram bench mark, and optical ruler for biosensing.
In this thesis, the two-staged Mach-Zehnder interferometer and broad band source are utilized to characterize the MRR phenomenon in spatial domains under different concentrations. One advantage for two-staged Mach-Zehnder interferometer is that the bench mark interferograms from the 1st stage can be taken as a reference point during biosensing. Then the different concentrations of the analytes will be analyzed using MATLAB for Gaussian curve fillitng. And the sensitivity and resolution can demonstrate 49 μm⁄μM and 1.53 nM, respectively.

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