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研究生: 張鐳耀
Lei-Yao Chang
論文名稱: 以虛擬A公司探討台灣以囓齒類PDX平台進行個人化精準醫療之可行性
Using Virtual Company A to Explore the Feasibility of Personalized Precision Medical Treatment in Taiwan with Rodents PDX Platform
指導教授: 張順教
Shun-Chiao Chang
口試委員: 張光第
Kuang-Ti Chang
張瑞娟
Jui-Chuan Chang
吳克振
Ko-Chen Wu
學位類別: 碩士
Master
系所名稱: 管理學院 - 管理學院MBA
School of Management International (MBA)
論文出版年: 2018
畢業學年度: 106
語文別: 中文
論文頁數: 86
中文關鍵詞: 個人化精準醫療五力分析價值鏈人類腫瘤異體移植模式
外文關鍵詞: PDX Strategy, Value Chain, Five Force,, Personalized and Precision Medicine
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  • 本研究的目的為探討作為已知的藥物篩選之用的『個人化精準醫療囓齒類PDX平台』,以及在台灣進行商業化服務的可行性。對於『個人化精準醫療囓齒類PDX平台』,本研究中顯示此平台具有提供醫師判斷藥物選擇資訊的能力,過半的受訪者表示在罹患癌症時願意使用此平台,心理預期願意支付的價格會因為得知預設平台使用費(45萬或55萬)資訊而隨之提高,此外,性別對於服務平台的心理預期價格有顯著差異,但對於使用平台的意願度沒有差異性。家庭總收入對使用意願有顯著的影響,但當獲知預設平台使用費用後,家庭總收入對使用意願的影響性即消失。『個人化精準醫療囓齒類PDX平台』則因面臨模式建構時間較長的技術限制,並有斑馬魚與類器官等替代平台的競爭可能,但依然是目前公認的藥物測試與篩選平台獲得較高信任度。因此強化價值鏈環節,保持平台技術與專業性的領先性,對於投入此市場的公司保持持續競爭力極具重要性。


    The aim of the study was to investigate the feasibility of the rodent PDX (patient-derived xenograft) model platform on personalized and precision medicine in Taiwan. he results demonstrated that the Rodent PDX model can provide useful information of choosing target drugs for Hospital doctors and more than half of the respondents showed their intentions on using rodent PDX platform while they are suffering from cancer. Their expected prices for PDX platform were increased while receiving the set prices. The anchor effect on pricing was discovered. Moreover, gender effect was found on expected price but not on the intention of using the platform. The household income significantly affected the intention of using the platform. However, once respondents got the information of the set prices, their household income effect has disappeared. On the other hand, the establishment of rodent PDX model takes times and it encounters the competitions from Zebra fish PDX model and Organoid platform. Nevertheless, rodents PDX platform are still publicly accepted as a platform for drug assessments with trust. From the strategy point of view, in the early stage of the market development, the patients in stage III or IV who would like to use PDX model platform can be seen as rare resource while reviewing the number of patients using target drugs, considering the percentage of willing using PDX model from the results of this study and the dominance from hospitals. Therefore, the company that would like to enter the market, it should gain as much market share as possible with its higher professional skills to convince hospitals and patients. However, the number of company/organization entering the market could be increased in the long term because more target drugs will be developed and used in the future. The market structure may be changed from Oligopoly market to fully competitive market. In order to maintain its advantage and avoid the coming of fully competitive market, strengthening each section of company’s value chain and keeping its leading role in profession skills is suggested.

    摘要 i Abstract ii 致謝 iii 目錄 iv 圖目錄 vi 表目錄 vii 第一章、緒論 1 第一節研究動機與目的 1 第二節研究方法與架構 3 第二章、文獻探討 5 第一節台灣10大疾病與10大癌症 5 第二節、免疫缺陷鼠的發展與使用 10 第三節人源性腫瘤異體移殖平台(Patient-Derived Xenograft, PDX) 13 第三章研究方法 20 第一節深度訪談(Depth Interviews) 21 第二節資料分析原則 21 第三節問卷調查 22 第四節五力分析與價值鏈分析 23 第四章、研究結果 28 第一節深度訪談結果 28 第二節問卷調查 34 第三節五力分析與價值鏈分析 41 第五章、結論與建議 54 第一節消費者意願 54 第二節競爭優勢 55 第三節研究限制與未來方向 57 文獻資料 58 附件1深度訪談逐字稿 62 附件2 網頁問卷題目與回答資料 71

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